DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and pam-1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	683	Identity:	176/683 - (25%)
Similarity:	298/683 - (43%)	Gaps:	93/683 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSI 95
            ||...:......|||...:|.||::||...|.   ..|:.|...|.:..::.|:.:.:|...:.|
Worm    67 ACGNPSAAVKFERLPTFAEPTHYNVRLSPCLN---QFSFDGHATIDVTIKEATDVLKVHAQSLLI 128

  Fly    96 ES-KKITLFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYV-LSVEFGRPMTMDQRDGYFIR 158
            :| ..||..|:.|    :|:..:.|.|..::|......|....| |..:|...:. |:..|::..
Worm   129 QSVSLITQPGDAS----KSLETSYDDKLNILTIKLPTTMQPQKVQLDFKFVGELN-DKMRGFYRS 188

  Fly   159 HYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLP--- 220
            .|.:...:||...| :.|...:.|...|.||||..||||:||:.......:..||.|.:..|
Worm   189 QYKDKNGTEKFLAS-TQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVISETPTAD 252

  Fly   221 -NREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMA 284
             .|:...:..|     |.:.::|:||:|...  .|..|.:.|.|..|............::..::
Worm   253 GKRKAVTFATS-----PKMSSYLVAFAVGEL--EYISAQTKSGVEMRVYTVPGKKEQGQYSLDLS 310

  Fly   285 PQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELI 349
            .:.:::.:....:..||.|.|.:.:.||...||||:|||.||...||:......:::|.:...::
Worm   311 VKCIDWYNEWFDIKYPLPKCDLIAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVALVV 375

  Fly   350 AHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAV---------------DHLQSKMGRRILLR 399
            |||:||:||.||:.|..::||||.||.|.:.:.:.|               |.|.|.||...|
Worm   376 AHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFKIWLHFLNDELASGMGLDAL-- 438

  Fly   400 YRESSMMYESQVGGISLVPLSSNASLNAETQLYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSF 464
              .:|...|.::..    |...:...::.|  |.|:.|:..||..:|....|..||:.::.:..:
Worm   439 --RNSHPIEVEIDN----PNELDEIYDSIT--YAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQY 495

  Fly   465 GSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVI--RNGS--------EVFL 519
            .::.....|.:|..||.:        :|..:|..||.|.|:|::.|.  ::|:        ..|:
Worm   496 SNAVTQDLWTALSEASGQ--------NVNELMSGWTQQMGFPVLKVSQRQDGNNRILTVEQRRFI 552

  Fly   520 KQGHALNRSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGY 584
            ..|....::|.  |.:|:|..:  ||...::|.:..|........:..:.| .:|:.||....|:
Worm   553 SDGGEDPKNSQ--WQVPITVAV--GSSPSDVKARFLLKEKQQEFTIEGVAP-GEWVKLNSGTTGF 612

  Fly   585 YRVNY-DELTWQLLATTLFNDF--RSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDE 646
            |||.| ||     :.|.:..|.  |.:.||:|..:::|:..|.|...::.:..:.|......|||
Worm   613 YRVEYSDE-----MLTAMLPDIASRRMPVLDRFGLINDLSALLNTGRVSIAQFVQVAASSAKEDE 672

  Fly   647 YEPLMAFVVGWTNGFWGISTESSFNIAKWLGIA 679
            |      ||      ||...|   .::|.|..|
Worm   673 Y------VV------WGAIDE---GMSKLLACA 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	120/468 (26%)
		ERAP1_C	574..>652	CDD:338125	24/80 (30%)
		dnaA	630..>701	CDD:234667	13/50 (26%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	124/475 (26%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	32/109 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020