DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Y67D8C.9

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001122826.1	Gene:	Y67D8C.9 / 177088	WormBaseID:	WBGene00022073	Length:	1144	Species:	Caenorhabditis elegans

Alignment Length:	741	Identity:	194/741 - (26%)
Similarity:	313/741 - (42%)	Gaps:	183/741 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LPAKVKPFHYDIRL-----LTHLESSANHSYTGIVKISIHAQ----KTTNQVVLHVGRVSIESKK 99
            ||..:.|:|||::|     .|||...||        ||||.:    .|.:::..|:| .:|:.::
Worm   182 LPLYILPYHYDLQLDFSQFDTHLFIRAN--------ISIHLESYGNSTEDEIQFHLG-PNIKMER 237

  Fly   100 ITLFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWK 164
            :.|..:...:..::.:....:|...::....|..|| |:|.:.:...:..:..||  :|..::.:
Worm   238 MRLRKDGKKFYAKTFKREESKKLGRISLRDPLQKGK-YILEMTYNMTICDEDVDG--VRCSLDNQ 299

  Fly   165 T--SEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQDY 227
            |  |.|.....:.|.....|...|.:|||.:|||||:::.|:|::....||      |..|..|:
Worm   300 TNSSLKATSFTTKFEPTLARAFFPCWDEPGVKATFNISVRHNKKYTVLSNM------PPVESHDH 358

  Fly   228 -VW------SVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAP 285
             .|      :|.:.||.:.|:||||::..|....|:.....||...|..:  ||.:..|..:.||
Worm   359 KSWEDQFKTTVFQTTPPMSTYLLAFAIGEFVKLESRTERGIPVTVWTYPE--DVMSMKFTLEYAP 421

  Fly   286 QILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLE--- 347
            .|.:.|:..|::..||.|:|.:...:|....|||:||||:....:....  |::....:|::
Worm   422 VIFDRLEDALEIPYPLPKVDLIAARNFHVGGMENWGLVVFEFASIAYTP--PITDHVNETVDRMY 484

  Fly   348 -------LIAHEMAHMWFDNLLGMDSYSDLWLTEGLA------------------GYFKSLAVDH 387
                   |||||.||.||.||:.|..:|:|:|.||.|                  .|:.|||...
Worm   485 NEFRIGKLIAHEAAHQWFGNLVTMRDWSELFLNEGFATFYVYEMMSTERPVTAQFEYYDSLASLI 549

  Fly   388 L-QSKMGRRILLRYRESSMMYESQVGGISLVPLSSNASLNAETQLYQKATSLTSMLIGFLGNETF 451
            | ||:...|:.| .||  :..||||.. |..|          |.||.|...|..||...:.:..|
Worm   550 LAQSEEDHRLSL-VRE--LATESQVES-SFHP----------TNLYTKGCVLIRMLRDLVSDFDF 600

  Fly   452 YDGLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRN--- 513
            ...::|::.:|::.|.:.|..:.||...::..|..:|   :..:::.|.:..|.|.:|:|||
Worm   601 KAAVRRYLRKNAYRSVSRDDLFASLPAYADHGAEQEK---LSHVLEGWFVNEGIPEITLIRNYDN 662

  Fly   514 --------------------------------------GSEVF---LKQGHALNR---------- 527
                                                  ||.:|   |..|:...:
Worm   663 EMMTISQRKTVHHEYRSFLKDRKASASVRYRGSRSAEDGSTLFDDALFDGYIEKKKDRRRKHRPI 727

  Fly   528 --------------------------SSSHLWWIPLTYLIEGGSLSKN---LKPKAWLSPNSHGI 563
                                      :|..||.||:||:.  |||..:   :..:.||...:...
Worm   728 RRKTSTPPSISPISRRDELRKPRRVGASQDLWTIPITYMF--GSLKTSEGQVIREFWLKNRTVSF 790

  Fly   564 KLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDV-------- 620
            ...:|.| ||.:|:|.:....||||||.|.|:|||.||..:...||..:|.|::.|.
Worm   791 GDAEISP-NQAVLVNPEWKYPYRVNYDLLNWKLLARTLHQNHLEINEKSRMQLILDAEYFLSNSV 854

  Fly   621 ---LFLWNQDLLAWSTALNVLKYIID 643
               |:|:....||..|.:.|:.:.||
Worm   855 NPHLYLYLLGYLAHETKMEVMLFGID 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	135/494 (27%)
		ERAP1_C	574..>652	CDD:338125	28/81 (35%)
		dnaA	630..>701	CDD:234667	5/14 (36%)
Y67D8C.9	NP_001122826.1	Peptidase_M1	182..584	CDD:279741	125/437 (29%)
Y67D8C.9	NP_001122826.1	M1_APN_2	190..652	CDD:189008	137/500 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020