DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	725	Identity:	164/725 - (22%)
Similarity:	308/725 - (42%)	Gaps:	120/725 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YKNVALYGLLLLLCLCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSA------NHSYTG 71
            |.|:.:.|              ||.....|.:.| |.|: |.:.|..::..|.      |.:::.
Worm   981 YDNLVVIG--------------KTPWEKTPNIDA-VFPY-YKLDLQVNIPGSGPYQWYENMTFSA 1029

  Fly    72 IVKISIHAQKTTNQVVLHVGRVSIESKKITLFGETSN-------YRLRSVRFNNDRKYMVV-TFN 128
            ...::......|:.:.::..|:..:...|.|:.|...       .....|..:.|:..:.: |.|
Worm  1030 TSTVTFQLVSPTSSITINAHRLMFDPVSIRLYNENDENAHTPIPIDFSKVMKDYDKGTVTIPTMN 1094

  Fly   129 QSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRN-WIRNTMPSFDEPS 192
            .::|....|.|.:|:...:..:..:|.....|:....:.|.|...:.|... ..|:.:|.:||||
Worm  1095 NTVLYPNQYSLFIEYTGFIFQNPDEGDASNTYLGGLNNRKGWIFTTDFEGGPGARSLLPCWDEPS 1159

  Fly   193 LKATFNVTMGHHKRFQSYGN-MKVQAVLPNREIQDYVWSVHEVTPT--IPTHLLAFSVNNFNCRY 254
            .|..|.|::.|.....:..| :.:|     |.|.|..|:..:...|  :.|:|||..|.:|
Worm  1160 YKGQFEVSVFHPTDMIALSNEVDIQ-----RTIYDNGWTTTKFATTNQMSTYLLALCVGHF---- 1215

  Fly   255 SQAASL--SPVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTE-- 315
            |..|::  :.|..|....|...:...||..:....::|::.......||:|:|.:.:.::...
Worm  1216 SNLATVTRTGVLTRVWTWSGMEQYGEFALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAG 1280

  Fly   316 AMENFGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYF 380
            ||||:||::......:...|...:::..:..|..|||:.|.||.:::.:|.::|::|.||.|.|:
Worm  1281 AMENWGLIIGEYSLFMFDPDYATTRDITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYW 1345

  Fly   381 KSLAVD------HLQSKMGRRILLRYRESSMMYESQVGGISLVPLSSNASLNAETQLYQKATSLT 439
            .:..:|      |..|....|..:.:  .::.|:. :.|:: .|:.|:.......:.|.|.::|.
Worm  1346 FANGIDNTFPEQHAYSIDYNRFYMNH--IALKYDC-IPGVA-KPVISDTPPVFGIEPYYKGSALL 1406

  Fly   440 SMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTW-----DVKSIMDTW 499
            ::|...|....|.:||..::.|..:.:::|...|.||.:|::|....|  |     ||.|.||.:
Worm  1407 NLLNNVLTPAVFQEGLSSYLTQYGYVNASPRNLWTSLTVAAQRHNITD--WNGQPLDVSSFMDPY 1469

  Fly   500 TMQSGYPLVTV-IRNGSEVFLKQGHALNRSSSHLWWIPLTYLIEGGSLSKNL-------KPKAWL 556
            |:|:.||::|: :|..|.|...|...:  |...||.:|| :....|:|..|.       ....||
Worm  1470 TLQTSYPIITLTLRGTSTVQANQQSCM--SDETLWNVPL-FTQTPGALDFNWFVNFTGGNDATWL 1531

  Fly   557 SPNSHGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSD-- 619
            .|...|.:::           |..:..:.|:|||:.:|..:...|.::..:::...||.::.|
Worm  1532 RPLPTGYRVD-----------NAGSTSFARINYDDKSWYSIQAQLLSNMNTMSSTTRAMLLDDAN 1585

  Fly   620 ----------------VLFLWNQDLLA-WSTALNVLKYIIDEDEYEP----LMAFVV-------- 655
                            .|:|.|:|.|| |..|:.....:::..:|:|    :..:|:
Worm  1586 FFYQSGRWEMTKFLDLTLYLVNEDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVS 1650

  Fly   656 --GW-TNGFW 662
              .| |||.|
Worm  1651 KFQWNTNGLW 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	108/480 (23%)
		ERAP1_C	574..>652	CDD:338125	20/100 (20%)
		dnaA	630..>701	CDD:234667	11/49 (22%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008
		ERAP1_C	640..931	CDD:314669
		Peptidase_M1	999..1402	CDD:279741	90/417 (22%)
		ERAP1_C	1542..1839	CDD:314669	26/119 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020