DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and mnp-1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_497878.1	Gene:	mnp-1 / 175564	WormBaseID:	WBGene00007139	Length:	781	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	134/729 - (18%)
Similarity:	261/729 - (35%)	Gaps:	168/729 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ENCYKNVALYGLLLLLCLCQVACS-AKTQLYDEPRLPAKVKPFHY-------DIR---LLTHLES 63
            |.|.:..||          .|:|: :::.|..:   |:|.:|.||       |:|   |..|::.
Worm   149 EKCAEIQAL----------PVSCTPSQSPLTSD---PSKFQPIHYVLNITIRDVRKPVLEGHMQL 200

  Fly    64 SANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFGETSNYRLRSVRFNNDRKYMVVTFN 128
            .|: :...:..||:|:.|..|          :|::.          |:..|..|......|...:
Worm   201 FAS-TKDQVQAISLHSVKIHN----------LENRD----------RIHVVNCNTGETICVSRVH 244

  Fly   129 Q-SLLMGKSYVLSVEFGRPMTMDQRDGYFIR----HYI------NWKTSEKIWYSVSHFNRNWIR 182
            | ..|:......|:..|..:.:| .||:...    |..      .|:..:.|.   |.|.....|
Worm   245 QIDDLIHLELAQSISSGVNLRVD-IDGFISADSGPHVFKQIPTAKWRVPQMIG---SVFEPTSAR 305

  Fly   183 NTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQDYVWSVHEVTPTIPTHL--LAF 245
            :..||||..:.|:|||:.:.|.....:..|..:...:....|..:    .:..|.|...|  :||
Worm   306 HVFPSFDLHNQKSTFNLCLNHGPSMSAIANSLINPNVSTSGISCF----EKTVPLIAQQLSFVAF 366

  Fly   246 SVNN---FNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQL 307
            ...|   :|......|.|..:.......:.:.:...:......:::..:.:....:.||.:::.:
Worm   367 EKTNPLFYNTTTMDGAYLPEIDMIFNLNAKNFKQYEWIHSEVSKVMALMSKWSGFSYPLTRLEIV 431

  Fly   308 VVDDFPTEAMEN-FGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLW 371
            |.   |.:|..: .|::...::.:..       ::...|.|.:..|:...|.:.::
Worm   432 VA---PVQAGHSALGVITLPAQAIAY-------QKHTSTHETLIKEVIGQWMEGVV--------- 477

  Fly   372 LTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQVGGISLVPLSSNA-SLNAETQLYQKA 435
            .||...  |:...:.:::.|:...:.:..:...|    :|..|....|:..| |:....|:..::
Worm   478 TTEHTC--FEKALIAYVEWKINEELQIVKKTRKM----EVSKIRPRNLNETADSVRVLRQIKSQS 536

  Fly   436 TSLTS--------MLIGFLGNETFYDGLQRHMWQNSFGSSTPDLF-WRSLQLASEREATFDKTWD 491
            ::|.|        .|....|.||.. |:.|.:: :.|..||..:. |     ||..|.......:
Worm   537 SNLCSPRFVEVFYTLDETYGQETVI-GMIRVIF-DKFAFSTATISDW-----ASAAETATGGRPE 594

  Fly   492 VKSIMDTWTMQS---GYPLVTVIRNGSEVFLKQGHALNRSSSHLWWIPLTYLIEGGSLSKNLKPK 553
            ..:::..|...|   ..|::..:.:.:.|      ..|:.:...|.:||..   .||....|
Worm   595 AGALIHQWYRPSSTISRPVLRAVVSSNSV------EFNQLTEETWTVPLEI---SGSAGTQL--- 647

  Fly   554 AWLSPNSHGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLATT-------------LFNDF 605
            |.:|.....|..    ..:.:::::.....:..|.||..|:..|...             :|:|.
Worm   648 AVISEKKQAIPF----VSSDYVVVDAGRKSHAFVVYDADTYLRLIRCFGDSRCPSKEIGGIFSDL 708

  Fly   606 RS---INVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEPLMAFVVGWT------NGF 661
            .:   .|:|.:.:         |||:..|.   :|.|::..::..|...|..|...      ..:
Worm   709 GAALLANILPKPE---------NQDVAKWK---SVFKFMAQQNIVEGTAACCVEHAIREMRKCSY 761

  Fly   662 WGIS---TESSFNI 672
            |.|.   |:..|||
Worm   762 WDIQDVCTKIDFNI 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	86/484 (18%)
		ERAP1_C	574..>652	CDD:338125	16/93 (17%)
		dnaA	630..>701	CDD:234667	12/52 (23%)
mnp-1	NP_497878.1	Peptidase_M1	172..556	CDD:279741	77/437 (18%)
		GluZincin	<294..>480	CDD:301352	34/211 (16%)
		GluZincin	<547..602	CDD:301352	13/61 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010