DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and F49B2.6

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_493503.2	Gene:	F49B2.6 / 173297	WormBaseID:	WBGene00009865	Length:	1082	Species:	Caenorhabditis elegans

Alignment Length:	658	Identity:	176/658 - (26%)
Similarity:	292/658 - (44%)	Gaps:	95/658 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RLPAKVKPFHYDIRL---LTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFG 104
            |||...:|..||:.|   ||:.|..|:      |.|.|..:..|..::|:...:.::|..||..|
Worm   199 RLPRTAEPIDYDLTLHPNLTNGEVEAS------VSIRILIKNDTKLLILNAENLEMKSFDITKKG 257

  Fly   105 ETSNYRLRSVRFNND-RKYMVVT-----FNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINW 163
                     .:...| .|..|:|     ..:.|..|...||::.:...|..|.:..||..|.  .
Worm   258 ---------AKVKADFVKCAVMTQWAWKLAKRLHKGDHIVLTIYYSAQMKSDLQGLYFSTHL--G 311

  Fly   164 KTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQD-Y 227
            ...:|...:.:.|...:.|..:|.||||:.||||.|.:..:....:..||.   :|.::|.:: .
Worm   312 TDGKKTKSAATQFEPTFARKMLPCFDEPNFKATFQVAIIRNPHHIARSNMN---ILISKEYKNGL 373

  Fly   228 VWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVR----------ATSFAAQ 282
            :..|.|.:..:.|:|||.:|.:   .|.....|:    |...::.:||          .:.|...
Worm   374 IKDVFEKSVKMSTYLLAVAVLD---GYGYIKRLT----RNTQKAIEVRLYAPQDMLTGQSEFGLD 431

  Fly   283 MAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLL--REDGPMSKEKLQT 345
            ...:.|||.:....::.||:|||.|.:|||...||||:|||.:|...||.  |:...::||.:..
Worm   432 TTIRALEFFEDYFNISYPLDKIDLLALDDFSEGAMENWGLVTFRDSALLFNERKASVVAKEHIAL 496

  Fly   346 LELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQ 410
              :|.||:||.||.||:.||.:::::|.||.|.|.:...|:||.....  |:.|:...::.:..:
Worm   497 --IICHEIAHQWFGNLVTMDWWNEVFLNEGFANYMEYKCVEHLFPDWS--IMSRFYAENLAFSQE 557

  Fly   411 VGGISLVPLSSNA--------SLNAETQL-YQKATSLTSMLIGFLGNETFYDG----LQRHMWQN 462
            ..|.    |||.|        .||....: |.||.::..|:....|.:.|.:.    |.::.:.|
Worm   558 PDGF----LSSRAIESDDDDSLLNLFDAINYHKAAAIIHMIAEMAGQKNFQNALVEYLNKYAYSN 618

  Fly   463 SFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEV---------F 518
            :.|   .|| |:.:    |:.|....|..:..:...:|.|.||||:||.|....|         |
Worm   619 AIG---VDL-WKIV----EKHANLQGTVSIPDLAKAYTTQVGYPLLTVERTDEGVLVHNQTRFLF 675

  Fly   519 LKQGHALNRSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVG 583
            .:...|..:.....|.||::|    .......|.:.|:..:...:...  ...|.|::||...||
Worm   676 AEGDKAEEKRGDWKWPIPISY----RDSEHRRKKQHWIQADDKNVTWE--TTSNDWLILNTGGVG 734

  Fly   584 YYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYE 648
            |::|.||..|::.|...|..:..:|:.::|:.|:.|...|....||..|...::|:|:  |.|.:
Worm   735 YFKVLYDPETYRKLVKQLQRNHTTISPIDRSMILVDSFDLSKTSLLNISVYFDLLEYV--EKETD 797

  Fly   649 PLMAFVVG 656
            .:...:||
Worm   798 KMTWSIVG 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	127/482 (26%)
		ERAP1_C	574..>652	CDD:338125	24/77 (31%)
		dnaA	630..>701	CDD:234667	7/27 (26%)
F49B2.6	NP_493503.2	Peptidase_M1	199..586	CDD:279741	117/421 (28%)
		M1_APN_2	207..654	CDD:189008	130/489 (27%)
		ERAP1_C	726..1037	CDD:288671	25/82 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020