DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Lnpep

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	724	Identity:	192/724 - (26%)
Similarity:	330/724 - (45%)	Gaps:	122/724 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KCLLSERENCYKNVALYGLLLLLCLCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANH 67
            :|..: :|.|:|......|:.     .:|.:.|...:.:.|||..:.|..|::.|..:|.|.
  Rat   133 RCTFT-KEGCHKTNQSAELIQ-----PIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSM--- 188

  Fly    68 SYTGIVKISIHAQKTTNQVVLH-----------VGRVSIESKKITLFGETSNYRLRSVRFNNDRK 121
            ::.|.|.||:.|.:.|..::||           :..||.:.|::    |...|..        .:
  Rat   189 TFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQV----EILEYPY--------HE 241

  Fly   122 YMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINW--KTSEKIWYSVSHFNRNWIRNT 184
            .:.|...:|||.|.:|.|.:|:...::    :.|:..:.|.:  |::||..::.:.|.....|:.
  Rat   242 QIAVVAPESLLTGHNYTLKIEYSANIS----NSYYGFYGITYTDKSNEKKNFAATQFEPLAARSA 302

  Fly   185 MPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNRE--IQDYVWSVHEVTPTI--PTHLLAF 245
            .|.||||:.||||.:.:...:...:..||..::.:|..|  |||      |.:.::  .|:|:||
  Rat   303 FPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQD------EFSESVKMSTYLVAF 361

  Fly   246 SVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQ--------------ILEFLDRVLQ 296
            .|.               ..|..:|  ||..|..:....|:              :|||.....:
  Rat   362 IVG---------------EMRNLSQ--DVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFE 409

  Fly   297 VALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLL-REDGPMSKEKLQTLELIAHEMAHMWFDN 360
            :..||:|:|.:.:.||...||||:||:.:|.:.||. .....::..||.| ::||||:||.||.|
  Rat   410 IQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVT-KIIAHELAHQWFGN 473

  Fly   361 LLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGR-RILLRYRESSMMYESQVGGISLVPLSSNAS 424
            |:.|..::||||.||.|.:.:..:|:.:..::.. ...|..|..:|..:|.   .|..|:||  |
  Rat   474 LVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSL---NSSHPISS--S 533

  Fly   425 LNAETQL--------YQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASE 481
            :.:..|:        |.|..||..||..:|..:.|...:..::..:|:.:...|..|.|.
  Rat   534 VQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSF----- 593

  Fly   482 REATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL--------NRSSSHLWWIPLT 538
            .|.| .||.|||.:|.|||:|.|:|||||.|.|:|:.|:|....        :..:||||.||::
  Rat   594 NEVT-GKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPIS 657

  Fly   539 YLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFN 603
            |:.:|.:.|: .:..:.|...|..|.|.:.|   ||:.:|....|||.|:|....|..|...|..
  Rat   658 YVTDGRNYSE-YRSVSLLDKKSDVINLTEQV---QWVKVNTNMTGYYIVHYAHDGWAALINQLKR 718

  Fly   604 DFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEPLMAFVVGWTNGFWGISTES 668
            :...::..:||.:::::..|.....:....|.:::.|:.:|....|:...:         ..|:.
  Rat   719 NPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEAL---------FQTDL 774

  Fly   669 SFNIAKWLG 677
            .:|:.:.||
  Rat   775 IYNLLEKLG 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	131/488 (27%)
		ERAP1_C	574..>652	CDD:338125	17/77 (22%)
		dnaA	630..>701	CDD:234667	8/48 (17%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	115/432 (27%)
		M1_APN_2	176..617	CDD:189008	135/494 (27%)
		Substrate binding. /evidence=ECO:0000250	428..432		2/3 (67%)
		ERAP1_C	690..1005	CDD:288671	20/103 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349270
Domainoid	1	1.000	45	1.000	Domainoid score	I11882
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950