DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and Anpep

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	760	Identity:	198/760 - (26%)
Similarity:	318/760 - (41%)	Gaps:	141/760 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YDEPRLPAKVKPFHYDIRLLTHL--ESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKI- 100
            :::.|||..:.|..|.:.|..:|  .:...:.:.|...:.....:||:.:::|       |||:
Mouse    71 WNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIH-------SKKLN 128

  Fly   101 -TLFGETSNYR--LRSV----RFNNDR-------KYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQ 151
             ||.|   |:|  ||::    ..|.|:       :|:||....||:.|:.|.:..:|...:. |.
Mouse   129 YTLKG---NHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELA-DD 189

  Fly   152 RDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQ 216
            ..|::...|:.....:.:  :.:.......|.:.|.||||::||.||:|:.:.....:..||..:
Mouse   190 LAGFYRSEYMEGDVKKVV--ATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPK 252

  Fly   217 AVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAA 281
            ...|..|......:....||.:.|:|||:.|:.|....|.:|:...:.......:.|.....:|.
Mouse   253 ESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYAL 317

  Fly   282 QMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTL 346
            .:...||.|..:....:.||.|.||:.:.||...||||:|||.||...|:..........|.:.:
Mouse   318 NVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVV 382

  Fly   347 ELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQV 411
            .:||||:||.||.||:.:..::||||.||.|.|.:.|..|:.:.        .:....:|..:.|
Mouse   383 TVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEP--------TWNLKDLMVLNDV 439

  Fly   412 GGISLV-------PLSSNA-SLNAETQL--------YQKATSLTSMLIGFLGNETFYDGLQRHMW 460
            ..:..|       ||||.| .:....|:        |.|..|:..||..||..:.|..||..::.
Mouse   440 YRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLH 504

  Fly   461 QNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL 525
            ...:.::.....|..||.|..::........|::|||.|.:|.|:|::||..|..|:  .|.|.|
Mouse   505 TYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGEI--SQKHFL 567

  Fly   526 NRSSS---------HLWWIPLTYLIEGG------SLSKNLKPKAWLSPNSHGIKLNDIVPRNQWI 575
            ..|.|         ::|..|:.:|..|.      .:.||...|...|             .|:||
Mouse   568 LDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWLDVEKNQSAKFQTS-------------SNEWI 619

  Fly   576 LLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSD------------------VLF 622
            |||:...|||.|||||..|:.|...|..|...|.|:|||||:.|                  .||
Mouse   620 LLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLF 684

  Fly   623 LWNQ-DLLAWSTALNVLKY---IIDEDE-YEPLMAFVV---------------GWT--------- 658
            |..: :.:.|..||:.|.|   :.|..| |.|:..::.               .|.
Mouse   685 LVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQ 749

  Fly   659 -NGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDKFVVQDPNQN 702
             |....|||..|..:.:...:..:.|:::         :::||.|
Mouse   750 YNEINAISTACSSGLKECRDLVVELYSQW---------MKNPNNN 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	125/480 (26%)
		ERAP1_C	574..>652	CDD:338125	37/100 (37%)
		dnaA	630..>701	CDD:234667	17/99 (17%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64
		Metalloprotease	69..966		198/760 (26%)
		M1_APN-Q_like	84..545	CDD:341064	126/481 (26%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		2/3 (67%)
		ERAP1_C	618..945	CDD:403137	47/177 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950