DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and lnpep

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_002933474.1	Gene:	lnpep / 100216271	XenbaseID:	XB-GENE-950921	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	680	Identity:	176/680 - (25%)
Similarity:	320/680 - (47%)	Gaps:	80/680 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KCLLSERENCYKNVALYGLLLLLCLCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANH 67
            ||..: ::.|::......|:.     .:|.:.|...:.:.|||..:||.||.:.|  |.:.:..:
Frog   132 KCTFT-KDGCHEKKHPLELVY-----PIATNGKVFPWAKSRLPNSIKPVHYVLTL--HPDMTTMY 188

  Fly    68 SYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLF-GETSNYR-LRSVRFNNDRKYMVVTFNQS 130
             :.|.|:|.::...::|.:|||...:.|....:::. |.|.:.. |....|..    :.:...:|
Frog   189 -FAGTVQIKLNITASSNNIVLHSSGLRIIKAHVSVTEGTTMDAEVLEYPTFEE----IAIILPES 248

  Fly   131 LLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINW-KTSEKIWYSVSHFNRNWIRNTMPSFDEPSLK 194
            |..||..:|::::    |.:....|:..:.|:: :...|...:.:.|.....|...|.||||:.|
Frog   249 LPKGKECLLTIQY----TSNFSSTYYGFYKIDYMEKGNKRSLAATQFEPLAARKVFPCFDEPAFK 309

  Fly   195 ATFNVTMGHHKRFQSYGNM---KVQAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQ 256
            :||.:.:..::...|..||   |...:.....:.:|..||:     :.|:|:||.|.:.. ..:|
Frog   310 STFQINIIRNQSMISLSNMPKAKTSTMSDGLLLDEYSTSVN-----MSTYLVAFIVGDIK-NTTQ 368

  Fly   257 AASLSPVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFG 321
            ..:.:.|......:..|  ...:|...|.::|.|......:|.||:|:|.:.:.||...||||:|
Frog   369 ETNDTLVSVYAVPEKMD--QVKYALDSAMKLLYFYSNYYNIAYPLKKLDLVAIPDFQAGAMENWG 431

  Fly   322 LVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVD 386
            |:.:|...||.:||.....:|....::||||:||.||.||:.|:.::||||.||.|.|.:.:::.
Frog   432 LITFRETALLYKEDSSSVADKQSITKVIAHELAHQWFGNLVTMEWWNDLWLNEGFATYMEYVSMS 496

  Fly   387 HLQSKM-GRRILLRYRESSMMYESQVGGISLVPLSSNASLNAETQ------------LYQKATSL 438
            .|..:: .....|:.|.:::..:|         |:::..::.:.|            .|.|..|:
Frog   497 SLFPELNSENSFLKMRFTALQKDS---------LNASHPISTDIQSPEQIEEMFDDLSYIKGASI 552

  Fly   439 TSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQS 503
            ..||..||..:.|:..:..::..:.:||:|.|..|.|:.:.:      :|..:||::|.|||.::
Frog   553 LLMLQAFLSEDVFHHCIMEYLQAHQYGSTTSDSLWDSMNVVT------NKNPNVKNMMKTWTQKA 611

  Fly   504 GYPLVTVIRNGSEVFLKQ---------GHALNRSSSHLWWIPLTYLIEGGSLSKNLKPKA---WL 556
            ||||||.:|.|.|:.::|         .||.|.|:  :|.|||||:....|   .::|:.   :|
Frog   612 GYPLVTALRKGEEITVQQERFLRTPSPDHATNAST--VWHIPLTYVTRKCS---GIEPQCDNIYL 671

  Fly   557 SPNSHG-IKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDV 620
            .....| |.::...|   |:..|:...|||.|:|....|..|...|..|...::..:||.::.|:
Frog   672 LKEVTGRINVSSEFP---WVKFNVNMTGYYIVDYGADGWDALIKQLLRDHTVLHSSDRANLIHDI 733

  Fly   621 LFLWNQDLLAWSTALNVLKYIIDEDEYEPL 650
            ..|.....:..:.|..:|.|:.:|....|:
Frog   734 FMLAGVGKVPLAKAFELLGYLANETNSAPI 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	117/466 (25%)
		ERAP1_C	574..>652	CDD:338125	20/77 (26%)
		dnaA	630..>701	CDD:234667	5/21 (24%)
lnpep	XP_002933474.1	M1_APN-Q_like	174..609	CDD:341064	118/468 (25%)
lnpep	XP_002933474.1	ERAP1_C	687..1003	CDD:378732	20/77 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020