DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tektin-A and Tekt5

DIOPT Version :9

Sequence 1:	NP_001260476.1	Gene:	Tektin-A / 34934	FlyBaseID:	FBgn0028902	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001277930.1	Gene:	Tekt5 / 70426	MGIID:	1917676	Length:	557	Species:	Mus musculus

Alignment Length:	515	Identity:	137/515 - (26%)
Similarity:	225/515 - (43%)	Gaps:	58/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LQADLQAG---VDQQQMQLADMRAEQYKQSNKPLRMEEVQFARSMDPEADDLRNPPCYLPQQGDE 143
            |||...||   |.|:..|...:...:|..:.:|....::..::::..|...:|.||..||.....
Mouse    21 LQALPPAGQEPVVQECYQPFHLPGYRYLNAWRPSVFHKIATSQTIPEECSGIRRPPTILPSLRSA 85

  Fly   144 LPHKDQLMPMGPIGPWASGKVDWSPMAGITGTRPVVDRYSITRYSPNEWRTRNHETVQVVNASLG 208
            |                                       ..||:|.:|...|  .:|:.||...
Mouse    86 L---------------------------------------FCRYTPRDWDRSN--DLQIRNAEAS 109

  Fly   209 RADKNRFSSTTEFLRL----SALVDKSQKETTDKLRIRSQLIGKWKNTLENAIKAMADEISTMEV 269
            |...:|.  |.:.||:    ..|:.:.|:.|:..|..|...:|.||:.|...:..:..|.|:|:.
Mouse   110 RLWASRL--TGDSLRIMQDKDQLIHQMQEGTSRNLGQRLSDLGFWKSELCYELDRLLTENSSMDT 172

  Fly   270 ERIKLRKSMVVLGVPESIAKECIEKRATRPDTELVRDQVEEELVNELALIA----EIRRLLMKTL 330
            .:.:|..:...:..|..:|.||:..|..|...:||.|.||:.|:.|:.|:.    ::|:|..:.
Mouse   173 LKRRLECAAEEVNCPLQVALECLYNREKRIGIDLVHDNVEKNLIREVDLLKCCQDQMRKLAKRI- 236

  Fly   331 DDFNSQQVENRTARQRLEYDWSDKKESYEIDTINTGLNNCSRTIMFRPGAVRQPPEQASEKYWEH 395
             ||  |..:||.|:..||.|..||..:..||.....|.:.|.:|.|..|..:.....:..:.|..
Mouse   237 -DF--QIRDNRDAQHSLERDIEDKSSAQYIDENCFNLRSTSDSISFFHGVEKFDGTVSIPETWAK 298

  Fly   396 FSMETLDECEKCRLKSVALRNTLNSTLMNAARDIRTQADVVEKALTSRINCTQEAVQRFENDLKN 460
            ||.:.:...:..|..|:.||..........:..:..|......|..:||:...:...:.:..|..
Mouse   299 FSNDNIRHAQNMRANSIRLREEAEHLFETLSDQMWKQFTNTNLAFNARISEETDVKNKLQTQLAK 363

  Fly   461 ILQGTADVENRIEQMKRRINSFDSSMKVAQTRMDNRSYRPNVENCRDLAQQELIDGVHTIQSSVS 525
            |||.....||.|..::|.|.:.:..:|:|||.:..|:.|||||.|||:.|..|::.|.||..::.
Mouse   364 ILQEIFQAENTIMLLERAIVAKEYPLKMAQTMLACRTRRPNVELCRDVPQFRLVNEVFTIDDTLQ 428

  Fly   526 ALLHELEEAERVKTDLVNSRARLEREIMLKRRSLFIDRERCMLMRSYYPSANTLSGAATS 585
            .|...|.|.:.....||.:::|||.|:.:|..:|.||:::||.||..:||...|:|...|
Mouse   429 TLKLRLRETQDTLQLLVMTKSRLEHELAIKANTLCIDKDKCMSMRKSFPSTPRLTGYTCS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tektin-A	NP_001260476.1	Tektin	192..571	CDD:281184	111/386 (29%)
Tekt5	NP_001277930.1	Tektin	95..474	CDD:281184	111/386 (29%)
Tekt5	NP_001277930.1	6 X 6 AA approximate tandem repeats of C-[GSK]-G-[GSPH]-A-[SLP]. /evidence=ECO:0000305	507..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59762
OrthoDB	1	1.010	-	-		D264325at33208
OrthoFinder	1	1.000	-	-		FOG0000711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930