DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tektin-A and TEKT3

DIOPT Version :9

Sequence 1:	NP_001260476.1	Gene:	Tektin-A / 34934	FlyBaseID:	FBgn0028902	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_114104.1	Gene:	TEKT3 / 64518	HGNCID:	14293	Length:	490	Species:	Homo sapiens

Alignment Length:	474	Identity:	136/474 - (28%)
Similarity:	222/474 - (46%)	Gaps:	29/474 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPCYLP-------QQGDELPHKDQL----MPMGP------------IGPWA--SGKVDWSPMAGI 172
            |..:||       ...|..||.:..    :|..|            :.|:.  |.:|..:.|...
Human    19 PTNFLPAISTMASSYRDRFPHSNLTHSLSLPWRPSTYYKVASNSPSVAPYCTRSQRVSENTMLPF 83

  Fly   173 TGTRPVVDRYSITRYSPNEWRTRNHETVQVVNASLGRADKNRFSSTTEFLRLSALVDKSQKETTD 237
            ...|...    .|||:|::|...|....|..|.|...::|.|..::...........|:|.:||.
Human    84 VSNRTTF----FTRYTPDDWYRSNLTNYQESNTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQ 144

  Fly   238 KLRIRSQLIGKWKNTLENAIKAMADEISTMEVERIKLRKSMVVLGVPESIAKECIEKRATRPDTE 302
            .|..|...||.||:.:.:.:..|..|.:.:...:.:|.::::....|..:|:||:..|..|...:
Human   145 NLGERVNDIGFWKSEIIHELDEMIGETNALTDVKKRLERALMETEAPLQVARECLFHREKRMGID 209

  Fly   303 LVRDQVEEELVNELALIAEIRRLLMKTLDDFNSQQVENRTARQRLEYDWSDKKESYEIDTINTGL 367
            ||.|:||.:|:.|:..|...:..:...||...:|...||.::..||.|.|||:.:|.||.....|
Human   210 LVHDEVEAQLLTEVDTILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAYRIDDKCHHL 274

  Fly   368 NNCSRTIMFRPGAVRQPPEQASEKYWEHFSMETLDECEKCRLKSVALRNTLNSTLMNAARDIRTQ 432
            .|.|..:.:..|..|.....:..:.|..|:.:.:...:..|..|..||:.:.:.|:..|.::..|
Human   275 RNTSDGVGYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIENLLVVTANEMWNQ 339

  Fly   433 ADVVEKALTSRINCTQEAVQRFENDLKNILQGTADVENRIEQMKRRINSFDSSMKVAQTRMDNRS 497
            .:.|..:.|:||..|.:|..:.:..|...||.....|..||.:|:.|....:.:||||||:|.|:
Human   340 FNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERT 404

  Fly   498 YRPNVENCRDLAQQELIDGVHTIQSSVSALLHELEEAERVKTDLVNSRARLEREIMLKRRSLFID 562
            .|||:|.|||:||..|::.||.:..::..|...|.:||.....||:.:|.||.::.:|..||:||
Human   405 RRPNIELCRDMAQLRLVNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYID 469

  Fly   563 RERCMLMRSYYPSANTLSG 581
            :|:||.||..||:...|.|
Human   470 QEKCMSMRKSYPNTLRLVG 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tektin-A	NP_001260476.1	Tektin	192..571	CDD:281184	114/378 (30%)
TEKT3	NP_114104.1	Tektin	99..478	CDD:281184	114/378 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59762
OrthoDB	1	1.010	-	-		D264325at33208
OrthoFinder	1	1.000	-	-		FOG0000711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.790