DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tektin-A and TEKT4

DIOPT Version :9

Sequence 1:	NP_001260476.1	Gene:	Tektin-A / 34934	FlyBaseID:	FBgn0028902	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_011508972.1	Gene:	TEKT4 / 150483	HGNCID:	31012	Length:	476	Species:	Homo sapiens

Alignment Length:	490	Identity:	131/490 - (26%)
Similarity:	218/490 - (44%)	Gaps:	62/490 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPCYLPQQGDELPHKDQLMPMGPIGPWASGKVDWSPMAGITGTRPVVDRYSITRYSPNEWRTRNH 197
            |||       |||.|:..:........:||....|              :..::|...||....:
Human     6 PPC-------ELPCKEYDVARNTGAYTSSGLATAS--------------FRTSKYLLEEWFQNCY 49

  Fly   198 ETVQVVNASLGRADKNRFSSTTEFLRLSALVDKSQKETTDKLRIRSQLIGKWKNTLENAIKAMAD 262
            .......|...::::.|..|........||..::|:::|..:..|.|....||:.|:..::|:|.
Human    50 ARYHQAFADRDQSERQRHESQQLATETQALAQRTQQDSTRTVGERLQDTHSWKSELQREMEALAA 114

  Fly   263 EISTMEVERIKLRKSMVVLGVPESIAKECIEKRATRPDTELVRDQVEEELVNELALIAEIRRLLM 327
            |.:.:..::.:|.:::....||.||..:.::.|..|....||||.||.||:.|..||..|:.||.
Human   115 ETNLLLAQKQRLERALDATEVPFSITTDNLQCRERREHPNLVRDHVETELLKEAELIRNIQELLK 179

  Fly   328 KTLDDFNSQQVENRTARQRLEYDWSDKKESYEIDTINTGLNNCSRTIMFRPGAVRQPPEQASEKY 392
            :|:....||...||..::..|.|||||.|:|.||......::.|..:...|.:.......::.:.
Human   180 RTIMQAVSQIRLNREHKETCEMDWSDKMEAYNIDETCGRHHSQSTEVQAHPYSTTFQESASTPET 244

  Fly   393 WEHFSMETLDECEKCRLKSVALRNTLNSTLMNAARDIRTQADVVEKALTSRINCTQEAVQRFEND 457
            ...|:.:.|...::.||.|..||..::..|.:.:.|:|.|.|.|..|...|....::|..:..:.
Human   245 RAKFTQDNLCRAQRERLASANLRVLVDCILRDTSEDLRLQCDAVNLAFGRRCEELEDARYKLHHH 309

  Fly   458 L------------------------KNILQG-----------------TADVENRIEQMKRRINS 481
            |                        ::|..|                 ..|.|:.:..:|:.|..
Human   310 LHKGHWSGLPSGHSPKTWVGPAWSRRSIYPGMGAQAQGELSCLQTLREITDQEHNVAALKQAIKD 374

  Fly   482 FDSSMKVAQTRMDNRSYRPNVENCRDLAQQELIDGVHTIQSSVSALLHELEEAERVKTDLVNSRA 546
            .::.:.|||||:..||:|||:|.|||.||..|:..|..:..|::||..:|.|||:...:|.:...
Human   375 KEAPLHVAQTRLYLRSHRPNMELCRDAAQFRLLSEVEELNMSLTALREKLLEAEQSLRNLEDIHM 439

  Fly   547 RLEREIMLKRRSLFIDRERCMLMRSYYPSANTLSG 581
            .||::|.....||||||::||..|:.||:...|:|
Human   440 SLEKDIAAMTNSLFIDRQKCMAHRTRYPTILQLAG 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tektin-A	NP_001260476.1	Tektin	192..571	CDD:281184	114/419 (27%)
TEKT4	XP_011508972.1	Tektin	44..464	CDD:281184	114/419 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2685
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59762
OrthoDB	1	1.010	-	-		D264325at33208
OrthoFinder	1	1.000	-	-		FOG0000711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108956
Panther	1	1.100	-	-	LDO	PTHR19960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.790