DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tektin-A and TEKT5

DIOPT Version :9

Sequence 1:	NP_001260476.1	Gene:	Tektin-A / 34934	FlyBaseID:	FBgn0028902	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_653275.1	Gene:	TEKT5 / 146279	HGNCID:	26554	Length:	485	Species:	Homo sapiens

Alignment Length:	500	Identity:	132/500 - (26%)
Similarity:	210/500 - (42%)	Gaps:	47/500 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LQAGVDQQQMQLADMRAEQYKQSNKPLRMEEVQFARSMDPEADDLRNPPCYLPQQGDELPHKDQL 150
            :||.|.|:..|...:...:|..|.:|....::...::...|:.....||..||.....|
Human    27 VQAPVIQECYQPYYLPGYRYLNSWRPSLFYKIANVQTCPDESTSTLRPPTILPTLRSAL------ 85

  Fly   151 MPMGPIGPWASGKVDWSPMAGITGTRPVVDRYSITRYSPNEWRTRNHETVQVVNASLGRADKNRF 215
                                             .:||||::|...|.  :||..|...|...:|.
Human    86 ---------------------------------FSRYSPHDWDQSNQ--LQVRGAEASRLWASRL 115

  Fly   216 SSTTEFLRL----SALVDKSQKETTDKLRIRSQLIGKWKNTLENAIKAMADEISTMEVERIKLRK 276
              |.:.:||    ..|..:.|:.|...|..|...||.||:.|...:..:..|...:|..:.:|..
Human   116 --TDDSMRLLQDKDQLTHQMQEGTCRNLGQRLSDIGFWKSELSYELDRLLTENQNLETVKRRLEC 178

  Fly   277 SMVVLGVPESIAKECIEKRATRPDTELVRDQVEEELVNELALIAEIRRLLMKTLDDFNSQQVENR 341
            :...:..|..:|.||:..|..|...:||.|.||:.|:.|:.|:...:..:.|.....:.|..:||
Human   179 AANEVNCPLQVALECLYHREKRIGIDLVHDNVEKNLIREVDLLKCCQEQMRKLAQRIDIQMRDNR 243

  Fly   342 TARQRLEYDWSDKKESYEIDTINTGLNNCSRTIMFRPGAVRQPPEQASEKYWEHFSMETLDECEK 406
            .|:..||.|..||..:..||.....|.|.|..|.|..|..:.....:..:.|..||.:.:...:.
Human   244 DAQHVLERDLEDKSSAQCIDEKCFNLRNTSDCISFFHGMEKIDGTISVPETWAKFSNDNIKHSQN 308

  Fly   407 CRLKSVALRNTLNSTLMNAARDIRTQADVVEKALTSRINCTQEAVQRFENDLKNILQGTADVENR 471
            .|..|:.||..........:..:..|......|..:||:...:...:.:..|...||.....||.
Human   309 MRANSIQLREEAEHLFETLSDQMWRQFTDTNLAFNARISEVTDVKNKLQTQLAKTLQEIFQAENT 373

  Fly   472 IEQMKRRINSFDSSMKVAQTRMDNRSYRPNVENCRDLAQQELIDGVHTIQSSVSALLHELEEAER 536
            |..::|.|.:.:..:||||||::.|:.|||:|.|||:.|.:|::.|.||..::..|...|.|.:.
Human   374 IMLLERSIMAKEGPLKVAQTRLECRTRRPNMELCRDIPQLKLVNEVFTIDDTLQTLKLRLRETQD 438

  Fly   537 VKTDLVNSRARLEREIMLKRRSLFIDRERCMLMRSYYPSANTLSG 581
            ....||.::.|||.|:.:|..:|.||:|:||.||..:|....|.|
Human   439 TLQLLVMTKCRLEHELAIKANTLCIDKEKCMGMRKTFPCTPRLVG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tektin-A	NP_001260476.1	Tektin	192..571	CDD:281184	110/382 (29%)
TEKT5	NP_653275.1	Tektin	94..473	CDD:308655	110/382 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59762
OrthoDB	1	1.010	-	-		D264325at33208
OrthoFinder	1	1.000	-	-		FOG0000711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.790