DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18109 and SPC98

DIOPT Version :9

Sequence 1:	NP_723933.1	Gene:	CG18109 / 34931	FlyBaseID:	FBgn0028901	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_014273.1	Gene:	SPC98 / 855597	SGDID:	S000005070	Length:	846	Species:	Saccharomyces cerevisiae

Alignment Length:	882	Identity:	167/882 - (18%)
Similarity:	290/882 - (32%)	Gaps:	268/882 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1183 HHQRYVIAAPRAIIKSFKSNPAYG--------WSPDDPNAPDFYEQLDQFFEVTGQKKYRAGCDI 1239
            |.|.:|......:..|.||....|        .|.|.|.....:.::::|.            |.
Yeast    23 HLQTFVSDVVNLLRSSTKSATQLGPLIDFYKLQSLDSPETTIMWHKIEKFL------------DA 75

  Fly  1240 LFASIQLRLSQVLKRIVRHAPKNTSFPDLITIVGVAQLEQLLTRKERAAY----ESMRWQSRDKG 1300
            || .||                ||.  |::..:.|.|  .||....||..    ..:..::....
Yeast    76 LF-GIQ----------------NTD--DMVKYLSVFQ--SLLPSNYRAKIVQKSSGLNMENLANH 119

  Fly  1301 DQDLS---AESLFTDALHGMMGYGS-------------PHLKLSSLTGRLQLRSPHHQESISE-- 1347
            :..||   |.|::|:|....|...|             |....||:|.| ||.:|::..:|.|
Yeast   120 EHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSSTYSSVTLR-QLSNPYYVNTIPEED 183

  Fly  1348 -----SYLLLA-------------------------LGHF----GYFYREL--KEHLARLAEQGD 1376
                 ||.|||                         |.|.    |..|:.|  |....|:.....
Yeast   184 ILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFESGLLHLIFEAGLLYQSLGYKVEKFRMLNISP 248

  Fly  1377 TALALRKCLQKYLLNLHQFYD--VQKRNPSSLLSLYRRTRDFQRNFEWLLEVFNNVQKAK---SI 1436
            ...||...:.:.|.|...|.:  |......||.||||             |::.|:.:.:   ..
Yeast   249 MKKALIIEISEELQNYTAFVNNLVSSGTVVSLKSLYR-------------EIYENIIRLRIYCRF 300

  Fly  1437 VVYLYKESSRRTGYQRNLLLKWLRLVIQPLIYNLH------------IWLLNGRLPSTDHDMFVI 1489
            ..:|.:.|......:.|:......|.|:.:..||.            .||..|.|.:|..:.|:.
Yeast   301 TEHLEELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIA 365

  Fly  1490 EQTKYSKVDEFWEKRYRITESFS-----GIFDPQLSEILISVGKTMEYSEKYLAINFESCVPRKE 1549
            |.|..:..|:  :..|.|...|:     .....:|:..:..:||:..:.|||
Yeast   366 ENTDTNGTDD--DFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKY------------- 415

  Fly  1550 VRCMLLETFDKFLR-----------HGDQEPLYNFVRNLHLEISSKVLKYLRKTKINPEYLFSGL 1603
              |..::..::|.:           .|.....:..:.:.:.||.:...:.|.: |.:...:...|
Yeast   416 --CKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIINDQYSEIVNHTNQILNQ-KFHYRDVVFAL 477

  Fly  1604 HKYIMLTDLNFIMEFINALESVLGEPESSF-NIQLFNEMKNKMLHKSVRDIYIDKSES------- 1660
            ...:::...:|:...|.....:|..|..|. |.:|...::..:...|:|.:......|
Yeast   478 KNILLMGKSDFMDALIEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLD 542

  Fly  1661 -------EGSRCWSKLILRWKMPTHWRALLGED----SKAYEVIFKAMWRF---HYVYY------ 1705
                   .||..|....|.:.:......:|..:    .|.|..||..:|||   :|.|.
Yeast   543 ARVLDLGHGSVGWDVFTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKS 607

  Fly  1706 -------------------VLNE--RVHRQQIRFQN--------HIECTYFEGLNDTLKCFSKLT 1741
                               ::|:  |:...:.:||.        ::.|...|...:..:...:..
Yeast   608 NDIIRSFKKIRGYNPLIRDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTE 672

  Fly  1742 NA------CLRLMNVLMEYFLDYLLEPAFARLLWYCRNA----------ITVDELLVANRKYLKT 1790
            |.      .:||.|..:|  |:.:|.|. |.:|....::          :.:|||...:..:|..
Yeast   673 NKSQNQFDLIRLNNGTIE--LNGILTPK-AEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTN 734

  Fly  1791 IILGSLQTKNLRK-----YLERLY--DLILQLDNKHWKFLRL-CQ-TSVEYVIRVR--------- 1837
            |:...|...|..:     |..:.|  .|:|.| |..::|::: |. ..:.|.|.::
Yeast   735 ILSHKLFATNTSEISVGDYSGQPYPTSLVLLL-NSVYEFVKVYCNLNDIGYEIFIKMNLNDHEAS 798

  Fly  1838 -------KEKPQSIFSTY--YRERMLQFRWTCQNYSD 1865
                   ....:.|.|.|  :::|:..||...:|..|
Yeast   799 NGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18109	NP_723933.1	Spc97_Spc98	1312..1796	CDD:282045	117/640 (18%)
SPC98	NP_014273.1	GCP_N_terminal	185..467	CDD:407574	57/312 (18%)
SPC98	NP_014273.1	Spc97_Spc98	476..823	CDD:398000	61/350 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19302
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840