Protein Alignment t-Grip91 and Grip163

DIOPT Version :10

• Sequence 1: NP_723933.1
• Gene: t-Grip91 / 34931
• FlyBaseID: FBgn0028901
• Length: 1931
• Species: Drosophila melanogaster
• Sequence 2: NP_648537.2
• Gene: Grip163 / 39365
• FlyBaseID: FBgn0026432
• Length: 1351
• Species: Drosophila melanogaster
• Alignment Length: 1272
• Identity: 220/1272 - (17%)
• Similarity: 381/1272 - (29%)
• Gaps: 571/1272 - (44%)

  Fly   766 PEKSEQFFAYKGSGKIIE-LQISE--STQLFLELEQYVQNEVENSNCLKVENSKNEDIADQI--- 824
            |:|.......|...||.| |..||  |:|..||:...|.:||          :||.|..|.:
  Fly    29 PKKQTAVLVAKKRSKIYESLLHSETMSSQDKLEMLHQVTSEV----------AKNPDRMDMLLRF 83

  Fly   825 -----KDPKDQSSLTHNLSIDICRECCDQENREMISPTCSHINHICKDNKSGQMVCADEVDKSED 884
                 ...|::|.:|.:.         |:||:..:         :.|..|:|
  Fly    84 QNLLEGQDKEESEITQDQ---------DEENQSEV---------VIKRIKAG------------- 117

  Fly   885 LSPLSLRIDEYTECCDLRINPEELNEFVDEKMMSPTLSQISQTSNLVK-LQVLKTMDEFLSDVSA 948
              ||.|               .|..|.|:|.:.......|:|.:..:| ||:     :..||:..
  Fly   118 --PLQL---------------IETIEIVEEALHPKAFPDINQMNRALKPLQL-----QPYSDILT 160

  Fly   949 INNTIVDEEVEIDTPMLV----------ESLREVSNEDLIINISEGFSDISPMSTPGHPPDDQDE 1003
            .:|..::...|...|.::          ||:..:.||               |..|.|||
  Fly   161 TSNLNINFPPEKLIPKIIPSTVIRMGLSESITRMRNE---------------MEKPMHPP----- 205

  Fly  1004 LSPILGQISKTVSDVKINILNEVDKSLSEITVKSVSAILQKRKSKEYFSNQHKSQDFDYLTDDLS 1068
              |.|..::|.|
  Fly   206 --PRLPVLAKKV----------------------------------------------------- 215

  Fly  1069 GESVVKVSPLKNVDRFISEWTQKNP-----SDSILGKPYPKNLRYTSETSELSESSERESLSRNS 1128
                  |:||::...|::   |..|     ||.:|             |:||       .:.||.
  Fly   216 ------VAPLEDERPFVA---QPGPEKHFVSDKLL-------------TNEL-------KILRNK 251

  Fly  1129 NQILYLCKSCNAMLNYSEEVNKYFAGDFCINKKKFKVSDRNDLSNLERKFRQKWHHQRYVIAAPR 1193
            |.:          |||.:|.
  Fly   252 NLV----------LNYLDEA--------------------------------------------- 261

  Fly  1194 AIIKSFKSNPAYGWSPDDPNAPDFYEQLDQFFEVTGQKKYRAGCDILFASIQLRLSQVLKRIVRH 1258
            .:|...|                                 :|.|.|  .|:...:|...|..:|.
  Fly   262 TLIDHLK---------------------------------KAACGI--ESLTFPISSADKLELRV 291

  Fly  1259 APKNTSFPDLITIVGVAQLEQLLTRKERAAYESMRWQSRDKGDQDLSAESLFTDALHGMMGYGSP 1323
            .| ||:.|.::                                     ..:..|..:..:..|..
  Fly   292 RP-NTTLPTML-------------------------------------PEVLADFANHFIRAGCA 318

  Fly  1324 HLKLSSLTGRLQLRSPHHQESISESYLLLALGHFGYFYRELKEHLARLAEQGDTALALRKCLQKY 1388
            .|:|||.|         ...:|:|              ..|:..|.|         |:|:.:..|
  Fly   319 FLRLSSRT---------KWNNIAE--------------MRLERPLNR---------AMRETIMDY 351

  Fly  1389 LLNLHQFYDVQKRNPSSLLSLYRRTRDFQRNFEWLLEVFNNVQKAKSIVVYL---YKESSR---R 1447
            |....||          ||||         ..:.|.::.||...|..::..|   ::...|   .
  Fly   352 LSTTRQF----------LLSL---------QADSLFQLLNNTSTAIQLLCQLDRMFENEPRLNLN 397

  Fly  1448 TGYQRNLLLK--WLRL-------VIQPLIY-----------NLHIWLLNGRLPSTDHDMFVIE-- 1490
            ||...:.||.  ||.:       .:..|||           .|..|:.:|.|..:.:::|:..
  Fly   398 TGITGSFLLSSIWLAIDTCGNKDFLHLLIYFLRCISRNYFIQLQRWIYHGELDESVNEIFISRCL 462

  Fly  1491 ------QTKYSKVDEFWEKRYRITESFSGIFDPQLSEILISVGKTMEYSEKYLAINFESCVPRKE 1549
                  ..:.||  ||::|.|::.......|.....|.::..||
  Fly   463 NTSPSFTNQCSK--EFFDKSYQVDNEAIPEFLVGCEEEILQCGK--------------------- 504

  Fly  1550 VRCMLLETFDKFLR-HGDQEPLYNF-VRNLHLEISSKVLKYLRKTKINPEYLFSGLHKYIMLTDL 1612
                    ::..|| :..|.|:::. ..::.:.::.:.||.:|:.                |.|
  Fly   505 --------YNLVLRAYNAQHPVFDVQYPDIVVCLTEQQLKNMRRN----------------LAD- 544

  Fly  1613 NFIMEFINALESVLGEPESSFNIQLFNEMKNKMLHK-----SVRDIYIDKSESEGSRCWSKLILR 1672
                                         |..:::|     |::.|:.|:..::  |.::.|:::
  Fly   545 -----------------------------KYAIIYKRFGWCSMQSIFEDRMATK--RVFANLMVK 578

  Fly  1673 WKMPTH---WRALLGEDSKAYEVIFKAMWRFHYVYYVLNERVHRQQIRF-QNHIECTYFEGLNDT 1733
             :...|   |.      .|..|:..||    :....:.|::::.:|.|. |||:|....:.:|:.
  Fly   579 -RTQAHLDAWA------QKQRELQIKA----NAQKKLQNDQLNAEQERIQQNHLEKRRQDIVNEL 632

  Fly  1734 LKCFSKLTNACLRLMNVLMEYFLDYLLEPA--FARLLWYCRNAITVDELLVANRKYLKTIILGSL 1796
              .|.:   .|.|:.:.|:|.....|.:..  .|.:|....:..||.:|..|:.......:..|.
  Fly   633 --AFQR---ECERMEDKLLEREKQELQKKVVQLAAVLSSSPDRSTVSDLSFASCIEEPDCLAESS 692

  Fly  1797 QTKN----------LRKYLERLYDLILQLDNKHWKFLRLCQTSVEYVIRVRKEKPQ----SIFST 1847
            ..|:          ..|.|::..::.|:            |...||...|..::|:    |:.:.
  Fly   693 SDKDDANTENSEDEATKQLDKTLNVPLE------------QPEAEYQADVDVDQPRGKECSLPNV 745

  Fly  1848 YYRERMLQFRWTCQNYSDVINEMKD-----------QFDLAMISFLLC---LHLADDDSLRSLAK 1898
            :..:|         ::|||||..:.           |..|:...|..|   :||.:.|.|::.|.
  Fly   746 FQYQR---------SHSDVINSNEHPTTQAEFNRNRQHGLSSDQFQQCHATVHLQESDLLKTAAS 801

  Fly  1899 RLDPEHYYMEKD-----NRLDLVQYFEFRRKLERKRS 1930
            .....|..:.:|     |..|..:..|.:|  .|||:
  Fly   802 TSSGLHAEIPQDINANLNCPDTKELTELQR--NRKRN 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
t-Grip91	NP_723933.1	GCP_N_terminal	1312..1591	CDD:465456	58/314 (18%)
		GCP_C_terminal	<1690..1906	CDD:461187	50/246 (20%)
Grip163	NP_648537.2	GCP_N_terminal	273..523	CDD:465456	65/371 (18%)
		EnvC	<532..>677	CDD:443969	36/208 (17%)
		GCP_C_terminal	1033..1335	CDD:461187