DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18109 and Tubgcp6

DIOPT Version :9

Sequence 1:	NP_723933.1	Gene:	CG18109 / 34931	FlyBaseID:	FBgn0028901	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_001156791.1	Gene:	Tubgcp6 / 328580	MGIID:	2146071	Length:	1769	Species:	Mus musculus

Alignment Length:	962	Identity:	176/962 - (18%)
Similarity:	314/962 - (32%)	Gaps:	303/962 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   968 SLREVSNEDLIINISEGFSDISPMSTPGHPPDDQDELSPILGQISKTVSDVKINILNEVDKSLSE 1032
            ||:.|:...|..|:   |.:.:....|     |..:| |:..::.....|:::..|......|.|
Mouse    36 SLKRVAYNALFANL---FQEDTHQRQP-----DSSKL-PVKNKVLMLSFDLRVGGLGPEADRLEE 91

  Fly  1033 ITVK----------SVSAILQ--------------KRKSKEYFSNQHKSQDFDYLTDDLSGESVV 1073
            :..|          .|:::|.              :||...:|:|:|..::..|...|....||.
Mouse    92 LVEKLEAAPDCPFVEVASVLDLLVQLAGSGPPQVLRRKRDYFFNNKHAGRNIPYSGYDCYDLSVF 156

  Fly  1074 KVSPLKNVDRFISEWTQKNPSDSILGKPYPKNLRY--TSETSELSESSERESLSRNSNQILYLCK 1136
            ::    :|..|||            |:   :||.:  ..|..::.|::....|.  :..:..:..
Mouse   157 EM----DVRSFIS------------GE---ENLCHHTVQEALQVMEAAPGTGLP--TVGLFSIGD 200

  Fly  1137 SCNAMLNYSEEVNKYFAGDFCINKKKF---------KVSDRNDLSNLERKFRQ---KWHHQRYVI 1189
            ||.........|:.:.|   .::.:.:         .|.|..|.|.|..|..|   :|..:
Mouse   201 SCGDRFERDTRVSLFGA---LVHSRTYDMDVRLDLPPVPDSADFSGLAIKVPQIVDQWEDE---- 258

  Fly  1190 AAPRAIIKSFKSNPAYGWSPDDPNAPDFYEQLDQF-----FEVTGQKKY-RAGCDILFASIQLRL 1248
                    .|:|  |...:||..:.|.....||.:     :|.:.::.: |.||
Mouse   259 --------GFQS--ASNLTPDSQSEPSMTPDLDLWEAVLTYEASKRRCWERIGC----------- 302

  Fly  1249 SQVLKRIVRHAPKNTSFPDLITIVGVAQLEQLLTRKERAAYESMRWQSRDKGD-QDLSA------ 1306
                      .|.:..             |..||...|.|::  |:.....|: |.||.
Mouse   303 ----------PPGHRE-------------EPYLTEAGRDAFD--RFCRLRHGELQALSGGLLQAP 342

  Fly  1307 -------ESLFTDALHGMMGYGSPHLKLSSLTGRLQLRSPHH-----QESISESYLLLALGHFGY 1359
                   ..|..|:|:.::|..|....|...|....:....|     .||||.  :|..:..:|.
Mouse   343 KPVLVEESELVKDSLNVLLGVVSATFSLCRPTQAFVVEPGVHVSGASPESISS--ILSEVAEYGT 405

  Fly  1360 FYRELKEH-----LARLAEQGDTALALRKCLQKYLLNLHQFYD--VQKRNPS-SLLSLYRRTRDF 1416
            .|..|...     :..|..:|....|....|::||    |:|.  |....|: |||::....:..
Mouse   406 CYTRLSHFSLQPVVGSLCSRGLVFQAFTSGLRRYL----QYYRACVLSTPPTLSLLTIGFLFKKL 466

  Fly  1417 QRNFEWLLEV--FNNVQKAKS------------IVVYLYKESSRRTGYQR-NLLLKWLRLVIQPL 1466
            .|...:|.|:  ...|..|.|            ::.|||:|:......:. .:||..|:...:|.
Mouse   467 GRQLRYLAELCGVGTVSLATSGEPRAVFPTGVKLLSYLYQEALDNCSNEHYPVLLSLLKTSCEPY 531

  Fly  1467 IYNLHIWLLNGRLPSTDHDMFVIEQTKY-SKVDEF-WEKRY----RITESFSGIFDPQLSEILIS 1525
            ...:|.|:.:|.......:..:....:| |..|:| |...|    :..|....:|...::..:..
Mouse   532 TRFIHDWVYSGVFRDVYGEFMIQVNHEYLSFRDKFYWTHGYVLISKEVEDCVPVFLKHIAHDVYV 596

  Fly  1526 VGKTMEYSEKYLAINFESCVPR----------------------KEVR---CMLLETFDKFLRHG 1565
            .|||:..        .:.|.||                      ||:.   .:.:...::..||.
Mouse   597 CGKTINL--------LKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHS 653

  Fly  1566 ----DQEPLYNFVRNLHL-----EISSKVLKYLRKTKINPEYLFSGLHKYIMLTDLNFIMEFINA 1621
                :::.|...:....|     |.:|:||..|...:: .|.:.....|......|.  .:|:..
Mouse   654 CISKEEKELRMEIAKQELIVHAREAASRVLSELSDRQM-AEQIAQDTRKREQFQRLK--EQFVKD 715

  Fly  1622 LESVLG------EPESSFNIQLFNEMK-----NKMLHKSVRDIYIDKSESEGSRCWSKLILRWKM 1675
            .|..|.      :.:.|:..:|.:..|     .:.|.:..|...:|
Mouse   716 QERRLAARQEELDDDFSYARELRDREKRLKALEEELERKARQALVD------------------- 761

  Fly  1676 PTHWRALLGEDSKAYEVIFKAMWRFHYVYYVLNERVHRQQIRFQNHIECTYFEGLNDTLKCFSKL 1740
              |:..|..|.::..:   ||:||      :...|:...::||           |.:..||..::
Mouse   762 --HYSKLSAEAARREQ---KALWR------IQRHRLESARLRF-----------LLEDQKCIQEM 804

  Fly  1741 TNACLRLMNVLM--------------------EYFLD-YLLEPAFARLLWYC 1771
                ||.|....                    |:..: :..:|.|..|.|.|
Mouse   805 ----LRDMEAQQPQEPPSVFPSTGSQVTSTGPEHAGEGHSCDPGFTELHWGC 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18109	NP_723933.1	Spc97_Spc98	1312..1796	CDD:282045	104/560 (19%)
Tubgcp6	NP_001156791.1	Spc97_Spc98	355..>611	CDD:282045	58/269 (22%)
		NBP1	<622..>752	CDD:285709	20/132 (15%)
		ARGLU	631..759	CDD:291991	22/130 (17%)
		Ehrlichia_rpt	672..1249	CDD:118064	39/229 (17%)
		DUF4200	689..785	CDD:290574	19/128 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..842		1/32 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..881
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1360
		Spc97_Spc98	<1403..1667	CDD:282045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810