DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18109 and TUBGCP3

DIOPT Version :9

Sequence 1:	NP_723933.1	Gene:	CG18109 / 34931	FlyBaseID:	FBgn0028901	Length:	1931	Species:	Drosophila melanogaster
Sequence 2:	NP_006313.1	Gene:	TUBGCP3 / 10426	HGNCID:	18598	Length:	907	Species:	Homo sapiens

Alignment Length:	914	Identity:	193/914 - (21%)
Similarity:	349/914 - (38%)	Gaps:	208/914 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 SELSESSERESLSRNSNQILYLCKSCNAMLNYSEEVNKYFAGDFCINKKKFKVSDRNDLSNLERK 1177
            |||......:.:.:|...||||      :|:.||:.          .::..|||....|  ..:.
Human    75 SELHRKLHSQGVLKNKWSILYL------LLSLSEDP----------RRQPSKVSSYATL--FAQA 121

  Fly  1178 FRQKWHHQRYVIAAPRAIIKSFKSNPAY----------------------GWSPDDPNAPDFYEQ 1220
            ..:..|...|..|.|:.:..|::...|.                      |.:|    ||...
Human   122 LPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAP----APQSL-- 180

  Fly  1221 LDQFFEVTGQKKYRAGC-DILFASIQLRLSQVLKRIVRHAPKNTSFPDLITIVGV-AQLEQLLTR 1283
                  :.||.....|. |.|...:..||:..|       ..|.......|..|| :.:.:.:||
Human   181 ------LPGQSNQAPGVGDCLRQQLGSRLAWTL-------TANQPSSQATTSKGVPSAVSRNMTR 232

  Fly  1284 KERAAYESMRWQSRDKGDQDLSAESLFTDALHGMMGYGSPHLKLSS------LTGRLQLRSPHHQ 1342
            ..|        :....|..:::..:|..|.|:...|....::|:::      :.|:..|     .
Human   233 SRR--------EGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANL-----S 284

  Fly  1343 ESISESYLLLALGHFGYFYRELKEHLAR--------LAEQGDTALALRKCLQKY--LLN-LH--- 1393
            .|:.::  .:.|...|:.:.:::.:..:        |..|...| ||.:.|::|  ||: ||
Human   285 RSLRDT--AVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCA-ALHQELREYYRLLSVLHSQL 346

  Fly  1394 QFYDVQKRN--PSSLLSLYRR---TRDFQRNFEWLLEVFNNVQKAK----SIVVYLYKESSRRTG 1449
            |..|.|..|  ..|.|:|.|.   |.|.:...:.|..:.::.|..|    :..|:.|    .:||
Human   347 QLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAY----TKTG 407

  Fly  1450 --YQRNLLLKWLRLVIQPLIYNLHIWLLNGRLPSTDHDMFVIEQTKYSKVDEFWEKRYRITESFS 1512
              |.|:|:...|.||..|::..|:.|:.:|.|..|.|:.||...... |.|..|..:|.:.:|
Human   408 DPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTV-KTDRLWHDKYTLRKS-- 469

  Fly  1513 GIFDPQLSEILISVGKTMEYSEKYL----AINF--ESCVPRKEVRCMLLETFDKFLRHGDQEPLY 1571
                      :|....||:.|.|.|    :|||  :.|..:.....|:..| .......|...|:
Human   470 ----------MIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVT-KSAESPQDAADLF 523

  Fly  1572 NFVRN--------LHLEISSKVLKYLRKTKINPEYLFSGLHKYIMLTDLNFIMEFINALESVLGE 1628
            ..:.|        .:.|.|..:|..|.|.....::: ..:.:|::|...:||...::.|:..|..
Human   524 TDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHM-QAMRRYLLLGQGDFIRHLMDLLKPELVR 587

  Fly  1629 PESSFNIQLFNEMKNKMLHKSVR--DIYIDKSE------------SEGSRCWSKLILRWKMPTHW 1679
            |.::    |:......:|..:||  :...|..|            |.|...|....|.:.:....
Human   588 PATT----LYQHNLTGILETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPI 648

  Fly  1680 RALLGEDSKA-YEVIFKAMWRFHYVYYVLNERVHRQQIRFQNHIECTYFEGLNDTLKCFSKLTNA 1743
            ..:...:..: |..:|..:||...:.|:|.:      || :.|: |.  ..|...:..||.:.:.
Human   649 ATVFTRECMSHYLRVFNFLWRAKRMEYILTD------IR-KGHM-CN--AKLLRNMPEFSGVLHQ 703

  Fly  1744 CLRLMNVL------MEYFLDY-LLEPAFARLLWYCRNAITVDELLVANRKYLKTIILGSLQTKNL 1801
            |..|.:.:      |:|::.: :||.::..|....:.|..:|.::.|:..:|.|||...|...:.
Human   704 CHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDS 768

  Fly  1802 RKYLERL---YDLILQLDNKHWKFLRLCQTSVEYVIRVRKEKPQSIFSTYYRERMLQFRWTC--- 1860
            |..|.:|   :|.|::|.|......|.....::..::..::|         ::|.::.:|..
Human   769 RALLNQLRAVFDQIIELQNAQDAIYRAALEELQRRLQFEEKK---------KQREIEGQWGVTAA 824

  Fly  1861 --QNYSDVINEMKDQF-----DLAMIS---------FLLCLHLADDDSLRSLAKRLDPEHYYMEK 1909
              :..:..|.|.|:..     .|.:::         ||:.|..:.|:|||.|:.|||...:|..:
Human   825 EEEEENKRIGEFKESIPKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAR 889

  Fly  1910 DNRL 1913
            :.||
Human   890 EPRL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18109	NP_723933.1	Spc97_Spc98	1312..1796	CDD:282045	121/550 (22%)
TUBGCP3	NP_006313.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..241		7/38 (18%)
		GCP_N_terminal	251..552	CDD:407574	76/326 (23%)
		Spc97_Spc98	555..886	CDD:398000	71/354 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19302
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840