DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and YKU80

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_013824.1	Gene:	YKU80 / 855132	SGDID:	S000004712	Length:	629	Species:	Saccharomyces cerevisiae

Alignment Length:	607	Identity:	125/607 - (20%)
Similarity:	215/607 - (35%)	Gaps:	147/607 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKECLIIVLDVRTCAAEEVKL-KSAKCVAEILKDKIVCDRK-DYVSFVLVGCDTDEIKTEDASHP 66
            :.|....::||.....:...: ||...:...|.:|....|| |::|..|..|...|...|   .|
Yeast     2 SSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLANCPVSENSQE---IP 63

  Fly    67 NVLPFGEPRLCSWQLLLEFFQFVNKTA-----------CE------DGEWLNG-----LQAALEL 109
            ||..           :..|...|..||           |:      ..|.|..     |..:|::
Yeast    64 NVFQ-----------IQSFLAPVTTTATIGFIKRLKQYCDQHSHDSSNEGLQSMIQCLLVVSLDI 117

  Fly   110 QNVATTLRVARRRILLLFDFNDFPQDYEKFNEITDEL--------LGEN----------IELIVG 156
            :......::.::.::...:.:|.....|:.:.:|:||        .|::          ::|:..
Yeast   118 KQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIILIDCGKDTQEERKKSNWLKLVEA 182

  Fly   157 THN---------IAYIDNAITS--QPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEAL 210
            ..|         :..|.:..||  :|..:|:...:.|.|.|:.|....|...:....||...||.
Yeast   183 IPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRLGADILSTQTSNPSGSMQDENCLCIKVEAF 247

  Fly   211 HTVFKVT--NRRPWV-----WNAKLNIGSKISISLQ-------GIIAMKNQTPVKLVKVWAEKDE 261
            .....|:  ||:..|     ...:..:|.|..|..:       ..::..:|:....:.|...||.
Yeast   248 PATKAVSGLNRKTAVEVEDSQKKERYVGVKSIIEYEIHNEGNKKNVSEDDQSGSSYIPVTISKDS 312

  Fly   262 IVIRETRHYIKGTEITPLPENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHFFGFIKRNAVPDEY 326
            :    |:.|..|.:...||..|:            |:.|.|..    |||...||:.|.|:|..:
Yeast   313 V----TKAYRYGADYVVLPSVLV------------DQTVYESF----PGLDLRGFLNREALPRYF 357

  Fly   327 FCGESLYLLVHQKHN-QSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTH- 389
            ...||.::....:.. ||..:...|||..:: .:|.|...:..|.|.:...|..|.|.|.:.::
Yeast   358 LTSESSFITADTRLGCQSDLMAFSALVDVML-ENRKIAVARYVSKKDSEVNMCALCPVLIEHSNI 421

  Fly   390 ------PATLYMLEVSYTSQHHFWDFPAL--RTT------KTECSEEQLNAI-DQLIDSTDL--- 436
                  ..:|.:..:.:.......|||.|  |||      |.|....|::.: :|.:||.|.
Yeast   422 NSEKKFVKSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSMDTDEL 486

  Fly   437 -ECTLRDTQQPRPWAQND-LLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKNFADVFW-- 497
             |..|.:..||......| .||..:|....|:|..|.|....::...::..:|:        |
Yeast   487 PEIPLGNYYQPIGEVTTDTTLPLPSLNKDQEENKKDPLRIPTVFVYRQQQVLLE--------WIH 543

  Fly   498 -------------RVPDPLEEK 506
                         .:||.|:.|
Yeast   544 QLMINDSREFEIPELPDSLKNK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	48/258 (19%)
		KU80	221..524	CDD:238445	73/335 (22%)
		Ku_PK_bind	562..663	CDD:285938
YKU80	NP_013824.1	vWFA	5..232	CDD:412136	43/240 (18%)
YKU80	NP_013824.1	KU80	244..583	CDD:238445	78/351 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53888
OrthoFinder	1	1.000	-	-		FOG0003754
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102536
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R647
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.880