DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and SEC14

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_013796.1	Gene:	SEC14 / 855103	SGDID:	S000004684	Length:	304	Species:	Saccharomyces cerevisiae

Alignment Length:	193	Identity:	47/193 - (24%)
Similarity:	76/193 - (39%)	Gaps:	52/193 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 TQQPR----PWAQNDLLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPL 503
            |||.:    .:.||  .|.||||.  ....:|..:.|.:.:   ..|:|:|..|.:   |:.|..
Yeast     3 TQQEKEFLESYPQN--CPPDALPG--TPGNLDSAQEKALAE---LRKLLEDAGFIE---RLDDST 57

  Fly   504 EEKSKRAAAIVKKLFPLRYSRAWQ-EKLLAKEQAENGVAVKSEPAEKEIPLPSDGVGLIDPISDF 567
                           .||:.||.: :..||||..||     .|...|:.     |...|  :.||
Yeast    58 ---------------LLRFLRARKFDVQLAKEMFEN-----CEKWRKDY-----GTDTI--LQDF 95

  Fly   568 ----RRVLASVH-TISNATERDAR---FQALAADT--RVVIITLLQRRKQNIGQLGELITLYR 620
                :.::|..: ...:.|::|.|   |:.|.|..  .:..:|..:|..:|:....|.:..||
Yeast    96 HYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYR 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693
		KU80	221..524	CDD:238445	20/84 (24%)
		Ku_PK_bind	562..663	CDD:285938	15/69 (22%)
SEC14	NP_013796.1	CRAL_TRIO_N	34..79	CDD:215024	17/70 (24%)
SEC14	NP_013796.1	SEC14	99..269	CDD:214706	13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900