DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ku80 and Ttpal

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_083788.2	Gene:	Ttpal / 76080	MGIID:	1923330	Length:	343	Species:	Mus musculus

Alignment Length:	324	Identity:	63/324 - (19%)
Similarity:	108/324 - (33%)	Gaps:	103/324 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DTDEIKTED---ASHPNVLPFGEP----RLCSWQLLLEFFQFVNKTACEDGEW-LNGLQAALEL- 109
            ::|.::|..   :...|.||...|    .:||  |..:......:...|..|| |..:||..::
Mouse     4 ESDSLRTSPSVASLSENELPLPPPDPPGYVCS--LTEDLVTKAREELQEKPEWRLRDVQALRDMV 66

  Fly   110 ----------QNVATTLRVARRRILLLFDFNDFPQDYEKFNEITDELLGENIELIVGTHNIAYID 164
                      .:.|..||..|.|   .||::                  ..::|:|..|...
Mouse    67 RKEYPYLSTSLDDAFLLRFLRAR---KFDYD------------------RALQLLVNYHGCR--- 107

  Fly   165 NAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRP--WV---W 224
               .|.|:...|.......|.||:.  .|:::|..:...|          .|...||  |:   :
Mouse   108 ---RSWPEVFSNLRPSALKDVLNSG--FLTVLPHTDPRGC----------HVLCIRPDRWIPSNY 157

  Fly   225 NAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIVIRETRHYIKGTEITPLPENLITGYML 289
            ....||.: :.::|:.:| ...:|.|..:.:.|:...:.:.:..|:      .|.....:.|.:.
Mouse   158 PITENIRA-VYLTLEKLI-QSEETQVNGIVILADYKGVSLSKASHF------GPFIAKKVIGILQ 214

  Fly   290 GGTPVPYDEAVLEPKEPHP-PGLHFFGFIK--------------------------RNAVPDEY 326
            .|.|:.. :||....||.. .|:  |..||                          ||.:|.||
Mouse   215 DGFPIRI-KAVHIVNEPRIFKGI--FAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRNILPKEY 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	34/177 (19%)
		KU80	221..524	CDD:238445	27/138 (20%)
		Ku_PK_bind	562..663	CDD:285938
Ttpal	NP_083788.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		6/25 (24%)
		CRAL_TRIO_N	57..103	CDD:215024	11/66 (17%)
		SEC14	122..278	CDD:238099	35/177 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900