DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and XRCC5

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_066964.1	Gene:	XRCC5 / 7520	HGNCID:	12833	Length:	732	Species:	Homo sapiens

Alignment Length:	733	Identity:	160/733 - (21%)
Similarity:	298/733 - (40%)	Gaps:	131/733 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASNKECLIIVLDVRTCAAEEVK------LKSAKCVAEILKDKIVCDRKDYVSFVLVGCD-TDEIK 59
            :.||..:::.:||....:..:.      .::.|.:...::.::..:.||.::.||.|.| ||...
Human     4 SGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPL 68

  Fly    60 TEDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALE-LQNVATTLRVARRRI 123
            :....:.|:.......|..:. |||..:...:...:..::|:.|..::: :|:.....:..:|.|
Human    69 SGGDQYQNITVHRHLMLPDFD-LLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHI 132

  Fly   124 LLLFDFNDFPQDYEKFNEITDELLGENIELIVGTHNIAYIDNAITSQPQAIFNFS---------R 179
                         |.|.:::.......:::|:  |::...|.::    |....||         |
Human   133 -------------EIFTDLSSRFSKSQLDIII--HSLKKCDISL----QFFLPFSLGKEDGSGDR 178

  Fly   180 KCGPDEL-------------NNQKYALSLVPRCNATL---------CSFKEALH--TVFKVTNRR 220
            ..||..|             ..||..|.:|.....:|         .||.|:|.  .|||...|.
Human   179 GDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERH 243

  Fly   221 PWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAE------KDEIVIRETRHYIKGTEITP- 278
            ...|..:|.|||.:||.   |.|.|:....::.|.|..      |.|.:.:||.:.:...:.|.
Human   244 SIHWPCRLTIGSNLSIR---IAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEV 305

  Fly   279 LPENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLYLLVHQKHN 341
            |.|::|.|:..|...||:.:...|..:....|..|  .||.|.:.|...:|.|..:..:...:.:
Human   306 LKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDD 370

  Fly   342 QSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHF 406
            ::|||.|.:|:.||...|...:....|..:.| ||:.|..|.:..:..  .|..:::.:......
Human   371 EAAAVALSSLIHALDDLDMVAIVRYAYDKRAN-PQVGVAFPHIKHNYE--CLVYVQLPFMEDLRQ 432

  Fly   407 WDFPALRTTKTEC-SEEQLNAIDQLIDSTDL----ECTLRDTQQPRPWAQNDLLPFDALPSIFEQ 466
            :.|.:|:.:|... :|.||||:|.||||..|    |.|  ||.:       ||.|...:|:...|
Human   433 YMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKT--DTLE-------DLFPTTKIPNPRFQ 488

  Fly   467 NVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEE---KSKRAAAIVKKLFPLRYSRAWQE 528
            .:...|..:.::..:....:.:.      .|.:.:|..|   ||:...:.:|.||||..::. ::
Human   489 RLFQCLLHRALHPREPLPPIQQH------IWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKK-KD 546

  Fly   529 KLLAKE----QAENGVAVKSEPAEK-----EIPLPSDG----VGLIDPISDFRRVLASVHTISNA 580
            ::.|:|    ..|:|...|....|:     .:...::|    ||.::|..:| |||..
Human   547 QVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENF-RVLVK------- 603

  Fly   581 TERDARFQALAADTRVVIITLLQRRK-----QNIGQLGELITLYRQSCIDFNTFLEYDKFAEELK 640
             ::.|.|:..:......|...|...:     ::|    :.|..:|:..|.|:....::.|.:.|:
Human   604 -QKKASFEEASNQLINHIEQFLDTNETPYFMKSI----DCIRAFREEAIKFSEEQRFNNFLKALQ 663

  Fly   641 KIALAKNRSEFWQDVMVD 658
            :....|..:.||:.|:.|
Human   664 EKVEIKQLNHFWEIVVQD 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	42/246 (17%)
		KU80	221..524	CDD:238445	82/319 (26%)
		Ku_PK_bind	562..663	CDD:285938	21/102 (21%)
XRCC5	NP_066964.1	Ku_N	9..244	CDD:397685	46/254 (18%)
		Leucine-zipper	138..165		4/32 (13%)
		KU80	244..543	CDD:238445	82/319 (26%)
		Ku_PK_bind	593..705	CDD:400921	21/102 (21%)
		EEXXXDL motif	720..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147645
Domainoid	1	1.000	53	1.000	Domainoid score	I11383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I5084
Isobase	1	0.950	-	0	Normalized mean entropy	S8037
OMA	1	1.010	-	-		QHG53888
OrthoDB	1	1.010	-	-		D185892at33208
OrthoFinder	1	1.000	-	-		FOG0003754
OrthoInspector	1	1.000	-	-		oto90531
orthoMCL	1	0.900	-	-		OOG6_102536
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R647
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.890