DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	426	Identity:	79/426 - (18%)
Similarity:	128/426 - (30%)	Gaps:	159/426 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALEL-----QNVATTLRVARRRILLL 126
            |...||.| :.||..|:: .:.:|....    |..|::|.|.:     .|...||    .|:|:|
Mouse   381 NTKVFGRP-ISSWTCLVD-LEGLNMRHL----WRPGVKALLRIIEVVEANYPETL----GRLLIL 435

  Fly   127 FDFNDFPQDYEKFNEITDELLGENIELIVGTHN------IAYIDNAITSQPQAIFNFSRKCGPDE 185
            .....||..:...:...|:.......:..|...      :.|||..|.              ||.
Mouse   436 RAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEII--------------PDF 486

  Fly   186 LNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPV 250
            |:.:         |   :|...|                      |..:..||.       :|..
Mouse   487 LSGE---------C---MCDVPE----------------------GGLVPKSLY-------RTAE 510

  Fly   251 KL----VKVWAEKDEIVIRETRHYIKGTEITPLPENLITGYMLGGTPVPYDEAVLE--------- 302
            :|    :|:|.|    .|.::....||.     |..::...:...:.:.:|..|.:
Mouse   511 ELENEDLKLWTE----TIYQSASVFKGA-----PHEILIQIVDASSVITWDFDVCKGDIVFNIYH 566

  Fly   303 -PKEPHPP-----GLHFFGFIKRN----------------AVPDEYFC--GESL----------- 332
             .:.|.||     |.|.......|                .|.....|  |||:
Mouse   567 SKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSHVTRWPGF 631

  Fly   333 YLLVHQKHNQ--SAAVKL----DALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPA 391
            |:|..:.|..  .||..|    |.|....|||.:   |..:|.|:.           :..:....
Mouse   632 YILQWKFHTMPACAATNLPRVDDVLASLQVSSHK---CKVMYYTEV-----------IGSEDFRG 682

  Fly   392 TLYMLEVSYTSQHHFWDFPALRTTKTECSEEQLNAI 427
            ::..||.|::.      |..|....|..|:.|.:::
Mouse   683 SMTSLESSHSG------FSQLSAATTSSSQSQSSSM 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	32/156 (21%)
		KU80	221..524	CDD:238445	47/261 (18%)
		Ku_PK_bind	562..663	CDD:285938
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		36/193 (19%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024
		CRAL_TRIO	326..490	CDD:279044	29/132 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900