DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and Sec14l3

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_072130.1	Gene:	Sec14l3 / 64543	RGDID:	620812	Length:	400	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	96/534 - (17%)
Similarity:	165/534 - (30%)	Gaps:	205/534 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 LVPRCNATLCSFKEALHTVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVW--- 256
            |.|:...||..|:|.:..|                           :.|:.|.....|:: |
  Rat     8 LSPKQAETLAKFRENVQDV---------------------------LPALPNPDDYFLLR-WLRA 44

  Fly   257 ----AEKDEIVIRETRHYIKGTEITPL----PENLITGYMLG--------GTPVPYDEAVLEPKE 305
                .:|.|.::|:...:.|..:|..:    |..:|..||.|        |.|:.||  ::.|.:
  Rat    45 RNFDLQKSEAMLRKYMEFRKTMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPLWYD--IIGPLD 107

  Fly   306 PHPPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAAV--KLDALVRALVSSDRAIL-CWK- 366
              |.|| .|...|::.:..:.   .....::|:...|:..:  |::.:|.........:. .||
  Rat   108 --PKGL-LFSVTKQDLLKTKM---RDCERILHECDLQTERLGRKIETIVMIFDCEGLGLKHFWKP 166

  Fly   367 ---IYSTKFNRPQMVVLLPRLADDTHPATL-YMLEVSYTSQHHFWDFP-ALRTTKTECSEEQLNA 426
               :|...|.          |.::.:|.|| :||.|..|..     || .....|...||:....
  Rat   167 LVEVYQEFFG----------LLEENYPETLKFMLIVKATKL-----FPVGYNLMKPFLSEDTRRK 216

  Fly   427 IDQLIDSTDLECTLRDTQQPRPWAQN--DLLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKD 489
            |..|.:|               |.:.  .|:..:.||:.|         ...:.|.|...|.|..
  Rat   217 IVVLGNS---------------WKEGLLKLISPEELPAHF---------GGTLTDPDGNPKCLTK 257

  Fly   490 KNFADVFWRVPDPLEEKSKRAAAIVKKLFPLRYSRAWQEKLLAKEQAENGVAV---KSEPAEKEI 551
            .|:..   .:|..:..:.:                       .|.|.|:.|.:   .|...|.||
  Rat   258 INYGG---EIPKSMYVRDQ-----------------------VKTQYEHSVQISRGSSHQVEYEI 296

  Fly   552 PLP---------SDGVGLIDPISDFRRVLASVHTISNATERDARFQALAADTRVVIITLLQRRKQ 607
            ..|         |||.                         |..|.        |.:......:|
  Rat   297 LFPGCVLRWQFSSDGA-------------------------DIGFG--------VFLKTKMGERQ 328

  Fly   608 NIGQLGELITLYRQ-----------SCIDFNTF-LEYDKFAE--ELKKIALAKNRSEFWQDVMV- 657
            ..|::.|::|..|.           :|.:...: |.:|....  ..||::       |..:|::
  Rat   329 KAGEMTEVLTSQRYNAHMVPEDGSLTCTEAGVYVLRFDNTYSFVHAKKVS-------FTVEVLLP 386

  Fly   658 -------DKQLGPL 664
                   |::|.|:
  Rat   387 DEGMQKYDEELTPI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	6/17 (35%)
		KU80	221..524	CDD:238445	59/332 (18%)
		Ku_PK_bind	562..663	CDD:285938	17/122 (14%)
Sec14l3	NP_072130.1	CRAL_TRIO_N	13..59	CDD:215024	12/73 (16%)
Sec14l3	NP_072130.1	SEC14	76..245	CDD:214706	44/215 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900