DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ku80 and sec14l8

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001093463.1	Gene:	sec14l8 / 558964	ZFINID:	ZDB-GENE-060526-180	Length:	395	Species:	Danio rerio

Alignment Length:	280	Identity:	48/280 - (17%)
Similarity:	91/280 - (32%)	Gaps:	90/280 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 FEQNVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEEKSKRAAAIVKKLFPLR------- 521
            |.:.|.|:|.:.....:....:.|:.:||             ..:::.|:::|....|
Zfish    19 FREKVQDVLPQCPSQSDHFLLRWLRARNF-------------NLQKSEAMLRKHIEFRKHMKVDT 70

  Fly   522 YSRAWQEKLLAKEQAENGVA---VKSEPAEKEIPLPSDGVGLIDPISDFRRVLASVHTISNATER 583
            .:..||...:..:....|:.   .:..|...::..|.|..||:...|....:.:.|.. ....::
Zfish    71 ITTEWQVPEVIDKYLSGGMCGHDREGSPVWYDVIGPLDPKGLMHSASKQDLIKSKVRD-CEILQK 134

  Fly   584 DARFQALAADTRVVIITLL---------QRRKQNIGQLGELITLYRQSCIDFNTFLEYDKFAEEL 639
            |...|:......:..||::         ...|..|...||::|::.            |.:.|.|
Zfish   135 DCDRQSERLGRNIESITMVYDCEGLGMKHLYKPAIETYGEVLTMFE------------DNYPEGL 187

  Fly   640 KKIALAKNRSEF-------------------------WQDVMVDKQLGPLVL------------G 667
            |::.:.|....|                         ||:|: .|.:.|..|            |
Zfish   188 KRLFVIKAPKLFPVAYNLVKHFLSEDTRRKVIVLGSNWQEVL-QKYIDPEELPAYYGGKLTDPDG 251

  Fly   668 EP------TLDDELALKAYY 681
            :|      |...|:. |:||
Zfish   252 DPKCRTRITFGSEIP-KSYY 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693
		KU80	221..524	CDD:238445	10/66 (15%)
		Ku_PK_bind	562..663	CDD:285938	21/134 (16%)
sec14l8	NP_001093463.1	CRAL_TRIO_N	13..59	CDD:215024	8/52 (15%)
		SEC14	78..246	CDD:214706	29/181 (16%)
		GOLD_2	304..382	CDD:290608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900