Protein Alignment Ku80 and xrcc5

DIOPT Version :10

• Sequence 1: NP_609767.2
• Gene: Ku80 / 34930
• FlyBaseID: FBgn0041627
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001017360.2
• Gene: xrcc5 / 449848
• ZFINID: ZDB-GENE-041008-108
• Length: 727
• Species: Danio rerio
• Alignment Length: 741
• Identity: 164/741 - (22%)
• Similarity: 281/741 - (37%)
• Gaps: 157/741 - (21%)

  Fly     5 KECLIIVLDV-----RTCAAEEVKLKSA-KCVAEILKDKIVCDRKDYVSFVLVGCD-TDEIKTED 62
            |..|::.:||     .:...:|...:.| |.:.:.::.::..:.||.:..||.|.| |......|
Zfish     6 KSALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPLAND 70

  Fly    63 ASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALE-LQNVATTLRVARRRILLL 126
            ..:.|:.......:..::||.|..:.: :...:..:||:.|...:: |||.....:..|..|.||
Zfish    71 GQYENITVHRHLMIPDFELLEEIEREL-QPGGQQADWLDALVVCMDLLQNETMGKKYDRLNIALL 134

  Fly   127 FDFN--------------------------DFPQDYEKFNEITDELLGENIELIVGTHNIAYIDN 165
            .|.|                          .||.|.|      ||..|..             |.
Zfish   135 TDLNIQTSEDQLDIIIQNLKKAGITLQFFLPFPVDVE------DEAGGGG-------------DA 180

  Fly   166 AITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATL---------CSFKEALH--TVFKVTNR 219
            |..|.|.:      :.|......|...|.:|....::|         .:|.:||.  ::||...|
Zfish   181 AGPSAPPS------RPGKGLSRQQTQGLEMVKHIMSSLEDEDGLEEVYTFSDALEKLSIFKRIER 239

  Fly   220 RPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWA-------EKDEIVIRETRHYIKGTEIT 277
            ||..|..:|.|||.:||.   |:..|..|..|:.|.|.       ::|: |.|||.:.:...:.|
Zfish   240 RPMAWPCQLTIGSSLSIR---IVGYKAVTEEKVKKSWTIVDAQSHQRDD-VKRETVYCLNDDDET 300

  Fly   278 PL-PENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLYLLVHQK 339
            .: .::.|.||..|...||:.:...|..:....|..|  .||.|:..:|...|.|..:..:...:
Zfish   301 EVQKDDTIQGYRYGSDIVPFSKVDEEQMKYKHDGKCFSVLGFTKQELIPRHQFMGSQVVKVFAPR 365

  Fly   340 HNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQH 404
            .::.|||.|.:|:|||.....|.:....|..:.| ||:....|.: ...:...|| :::.|....
Zfish   366 DDEHAAVALSSLIRALDGLKMAAIVRYAYDRRSN-PQVGAAFPCI-KKKYECLLY-VQLPYMEDL 427

  Fly   405 HFWDFPALRTTKTEC-SEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNV 468
            ..:.||.|...|... |..||:|:|.||||..|      .::.......::...:.:|:...|.:
Zfish   428 RQFTFPMLENNKKFMPSGSQLSAVDALIDSMML------MEKDENGESVEIFKVNHIPNPQFQRL 486

  Fly   469 MDILERKVIYDND---KEDKMLKDKNFADVFWRV---PDPLEEKSKRAAAIVKKLFPLRYSRAWQ 527
            ...|..:.:..:|   ..|..||         ||   |..:..:.:.....||..|||:.....:
Zfish   487 FQCLHHRGVNPDDPLPPVDPWLK---------RVLERPQAVSARCQAPLRDVKTSFPLKVVVKKK 542

  Fly   528 EKLLAKEQAENGVAVKSEPAEKEIPLPSD--------------GVGLIDPISDFRRVLASVHTIS 578
            |:   |..|:...:...||..|::.:..:              .||.::|..||..::
Zfish   543 EQ---KTSADVFGSSADEPDAKKVKVNEETEFNLAEITEGNITSVGSVNPARDFCTLI------- 597

  Fly   579 NATERDARFQALAADTRVVIITLLQRRKQNIGQLG--------ELITLYR-QSCIDFNTFLEYDK 634
                   |.:.::.|.....:|  .|.:|.:|...        ..|..:| ||.:..|..| ::.
Zfish   598 -------RQKTVSFDQACQQLT--HRIEQLLGNRSTEYYTKSIACIQAFRDQSVLSGNAEL-FNS 652

  Fly   635 FAEELKKIALAKNRSEFW----QDVM 656
            :.:.||:....::..:||    ||.:
Zfish   653 YLQSLKRSIADRSLQDFWNLLAQDAL 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:427470	49/250 (20%)
		KU80	221..524	CDD:238445	81/319 (25%)
		Ku_PK_bind	562..>659	CDD:462604	21/108 (19%)
xrcc5	NP_001017360.2	vWFA	6..231	CDD:469594	50/250 (20%)
		KU80	241..535	CDD:238445	79/315 (25%)
		Ku_PK_bind	588..701	CDD:462604	21/108 (19%)