DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and xrcc5

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001017360.2	Gene:	xrcc5 / 449848	ZFINID:	ZDB-GENE-041008-108	Length:	727	Species:	Danio rerio

Alignment Length:	741	Identity:	164/741 - (22%)
Similarity:	281/741 - (37%)	Gaps:	157/741 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KECLIIVLDV-----RTCAAEEVKLKSA-KCVAEILKDKIVCDRKDYVSFVLVGCD-TDEIKTED 62
            |..|::.:||     .:...:|...:.| |.:.:.::.::..:.||.:..||.|.| |......|
Zfish     6 KSALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPLAND 70

  Fly    63 ASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALE-LQNVATTLRVARRRILLL 126
            ..:.|:.......:..::||.|..:.: :...:..:||:.|...:: |||.....:..|..|.||
Zfish    71 GQYENITVHRHLMIPDFELLEEIEREL-QPGGQQADWLDALVVCMDLLQNETMGKKYDRLNIALL 134

  Fly   127 FDFN--------------------------DFPQDYEKFNEITDELLGENIELIVGTHNIAYIDN 165
            .|.|                          .||.|.|      ||..|..             |.
Zfish   135 TDLNIQTSEDQLDIIIQNLKKAGITLQFFLPFPVDVE------DEAGGGG-------------DA 180

  Fly   166 AITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATL---------CSFKEALH--TVFKVTNR 219
            |..|.|.:      :.|......|...|.:|....::|         .:|.:||.  ::||...|
Zfish   181 AGPSAPPS------RPGKGLSRQQTQGLEMVKHIMSSLEDEDGLEEVYTFSDALEKLSIFKRIER 239

  Fly   220 RPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWA-------EKDEIVIRETRHYIKGTEIT 277
            ||..|..:|.|||.:||.   |:..|..|..|:.|.|.       ::|: |.|||.:.:...:.|
Zfish   240 RPMAWPCQLTIGSSLSIR---IVGYKAVTEEKVKKSWTIVDAQSHQRDD-VKRETVYCLNDDDET 300

  Fly   278 PL-PENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLYLLVHQK 339
            .: .::.|.||..|...||:.:...|..:....|..|  .||.|:..:|...|.|..:..:...:
Zfish   301 EVQKDDTIQGYRYGSDIVPFSKVDEEQMKYKHDGKCFSVLGFTKQELIPRHQFMGSQVVKVFAPR 365

  Fly   340 HNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQH 404
            .::.|||.|.:|:|||.....|.:....|..:.| ||:....|.: ...:...|| :::.|....
Zfish   366 DDEHAAVALSSLIRALDGLKMAAIVRYAYDRRSN-PQVGAAFPCI-KKKYECLLY-VQLPYMEDL 427

  Fly   405 HFWDFPALRTTKTEC-SEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNV 468
            ..:.||.|...|... |..||:|:|.||||..|      .::.......::...:.:|:...|.:
Zfish   428 RQFTFPMLENNKKFMPSGSQLSAVDALIDSMML------MEKDENGESVEIFKVNHIPNPQFQRL 486

  Fly   469 MDILERKVIYDND---KEDKMLKDKNFADVFWRV---PDPLEEKSKRAAAIVKKLFPLRYSRAWQ 527
            ...|..:.:..:|   ..|..||         ||   |..:..:.:.....||..|||:.....:
Zfish   487 FQCLHHRGVNPDDPLPPVDPWLK---------RVLERPQAVSARCQAPLRDVKTSFPLKVVVKKK 542

  Fly   528 EKLLAKEQAENGVAVKSEPAEKEIPLPSD--------------GVGLIDPISDFRRVLASVHTIS 578
            |:   |..|:...:...||..|::.:..:              .||.::|..||..::
Zfish   543 EQ---KTSADVFGSSADEPDAKKVKVNEETEFNLAEITEGNITSVGSVNPARDFCTLI------- 597

  Fly   579 NATERDARFQALAADTRVVIITLLQRRKQNIGQLG--------ELITLYR-QSCIDFNTFLEYDK 634
                   |.:.::.|.....:|  .|.:|.:|...        ..|..:| ||.:..|..| ::.
Zfish   598 -------RQKTVSFDQACQQLT--HRIEQLLGNRSTEYYTKSIACIQAFRDQSVLSGNAEL-FNS 652

  Fly   635 FAEELKKIALAKNRSEFW----QDVM 656
            :.:.||:....::..:||    ||.:
Zfish   653 YLQSLKRSIADRSLQDFWNLLAQDAL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	49/250 (20%)
		KU80	221..524	CDD:238445	81/319 (25%)
		Ku_PK_bind	562..663	CDD:285938	21/108 (19%)
xrcc5	NP_001017360.2	vWFA	8..241	CDD:294047	52/258 (20%)
		KU80	241..535	CDD:238445	79/315 (25%)
		Ku_PK_bind	588..700	CDD:285938	21/108 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581463
Domainoid	1	1.000	52	1.000	Domainoid score	I11528
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5113
OMA	1	1.010	-	-		QHG53888
OrthoDB	1	1.010	-	-		D185892at33208
OrthoFinder	1	1.000	-	-		FOG0003754
OrthoInspector	1	1.000	-	-		oto40079
orthoMCL	1	0.900	-	-		OOG6_102536
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910