DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and ttpal

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_021325407.1	Gene:	ttpal / 321577	ZFINID:	ZDB-GENE-030131-296	Length:	360	Species:	Danio rerio

Alignment Length:	277	Identity:	52/277 - (18%)
Similarity:	90/277 - (32%)	Gaps:	108/277 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 DRAILCWKIYSTKFNRPQMVVLL----------PRLADDTHPATL-YMLEVSYTS-------QHH 405
            |.|.|...:.:.||:..:.:.||          |.:..|..|:|: ::|::.:.:       |..
Zfish    95 DDAFLLRFLRARKFDYDRALQLLLNYHASRRAWPEVFQDLKPSTVKHVLDLGFLTVLPRPDPQGR 159

  Fly   406 F--------W---DFPALRTTKT---------ECSEEQLNAIDQLIDSTDLECTLRDTQQPRPWA 450
            :        |   |:|.:...:.         :..|.|:|.:..|:|...:  .|.....|.|
Zfish   160 YILCLRPGKWKPNDYPFVDNIRAIYLTLEKLIQPEETQVNGVVILVDYAGV--GLSQASNPGP-- 220

  Fly   451 QNDLLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKN-------FADVFWRVPDPLEEK-- 506
                        :..:.|:.||:       |.....:|..|       |..:|..:...|:||
Zfish   221 ------------LLAKKVVGILQ-------DGFPIRIKAVNIINEPRIFKGIFAIIKPFLKEKMA 266

  Fly   507 -------SKRAA---AIVKKLFPLRYS--------RAWQEKLLAKEQAENGVAVKSEPAEKEI-- 551
                   |..|:   .|.:.:.|..|.        .||...||              .||:|.
Zfish   267 ERYVLHGSDLASLHRVIPQSVLPQEYGGVSGRLDMSAWSRTLL--------------EAEEEFVV 317

  Fly   552 ----PLPSDGVGLIDPI 564
                |.|.:||.:.|.:
Zfish   318 EFCQPDPLEGVIMPDAL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693
		KU80	221..524	CDD:238445	40/229 (17%)
		Ku_PK_bind	562..663	CDD:285938	1/3 (33%)
ttpal	XP_021325407.1	CRAL_TRIO_N	74..120	CDD:215024	7/24 (29%)
ttpal	XP_021325407.1	SEC14	142..294	CDD:238099	29/174 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900