DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and Ttpal

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001100007.1	Gene:	Ttpal / 296349	RGDID:	1305754	Length:	343	Species:	Rattus norvegicus

Alignment Length:	325	Identity:	61/325 - (18%)
Similarity:	105/325 - (32%)	Gaps:	105/325 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DTDEIKTEDASHPNVLPFGEPRL-----------CSWQLLLEFFQFVNKTACEDGEW-LNGLQAA 106
            ::|.::|.    |:|....|..|           ||  |..:......:...|..|| |..:||.
  Rat     4 ESDSVRTS----PSVASLSENELPPPPPEPPGYVCS--LTEDLVTKAREELQEKPEWRLRDVQAL 62

  Fly   107 LEL-----------QNVATTLRVARRRILLLFDFNDFPQDYEKFNEITDELLGENIELIVGTHNI 160
            .::           .:.|..||..|.|   .||::                  ..::|:|..|..
  Rat    63 RDMVRKEYPYLSTSLDDAFLLRFLRAR---KFDYD------------------RALQLLVNYHGC 106

  Fly   161 AYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRP--WV 223
            .      .|.|:...|.......|.||:.  .|:::|..:...|          .|...||  |:
  Rat   107 R------RSWPEVFSNLRPSALKDVLNSG--FLTVLPHTDPRGC----------HVLCIRPDRWI 153

  Fly   224 ---WNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIVIRETRHYIKGTEITPLPENLIT 285
               :....||.: |.::|:.:| ...:|.|..|.:.|:...:.:.:..|:      .|.....:.
  Rat   154 PSNYPITENIRA-IYLTLEKLI-QSEETQVNGVVILADYKGVSLSKASHF------GPFIARKVI 210

  Fly   286 GYMLGGTPVPYDE--------------AVLEPKEPHPPGLHFF----------GFIKRNAVPDEY 326
            |.:..|.|:....              |:::|.........||          ..:.||.:|.||
  Rat   211 GILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLSSLHTSLPRNILPKEY 275

Fly 327 326
Rat 276 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	34/181 (19%)
		KU80	221..524	CDD:238445	25/135 (19%)
		Ku_PK_bind	562..663	CDD:285938
Ttpal	NP_001100007.1	CRAL_TRIO_N	57..103	CDD:215024	11/66 (17%)
Ttpal	NP_001100007.1	SEC14	122..278	CDD:238099	33/174 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900