DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and SEC14L4

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_016884276.1	Gene:	SEC14L4 / 284904	HGNCID:	20627	Length:	465	Species:	Homo sapiens

Alignment Length:	498	Identity:	90/498 - (18%)
Similarity:	158/498 - (31%)	Gaps:	162/498 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GCDTDEIKTEDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAAL---ELQNVA 113
            ||.....::....||.....|    ..|.::.|                 ||.|.|   |:....
Human    25 GCPIFRWQSRSGQHPAWSSGG----VDWWMMWE-----------------GLGAGLVAPEVMRAP 68

  Fly   114 TTLRVA----RRRILLLFDFNDFPQDY--------EKFN-EITDELLGENIELIVGTHNIAYIDN 165
            .|:|.:    |..:..|........||        ..|: :.::::|..::|.    .....:||
Human    69 PTIRSSSAQFRENLQDLLPILPNADDYFLLRWLRARNFDLQKSEDMLRRHMEF----RKQQDLDN 129

  Fly   166 AITSQPQAI---FNFSRKCGPD------------ELNNQKYALSL----VPRCNATLCSFKEALH 211
            .:|.||..:   ::....||.|            .|:.:...||.    :.|....:|..  .||
Human   130 IVTWQPPEVIQLYDSGGLCGYDYEGCPVYFNIIGSLDPKGLLLSASKQDMIRKRIKVCEL--LLH 192

  Fly   212 TVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIV-----IRETRH-- 269
            .....|.:          :|.||.::|. :..|:.   :.|..:|....|:.     |.|..:
Human   193 ECELQTQK----------LGRKIEMALM-VFDMEG---LSLKHLWKPAVEVYQQFFSILEANYPE 243

  Fly   270 ------YIKGTEITPLPENLITGYM----------LGGT--------------PVPYDEAVLEPK 304
                  .|:..::.|:..||:..:|          ||..              ||.:...:.:|
Human   244 TLKNLIVIRAPKLFPVAFNLVKSFMSEETRRKIVILGDNWKQELTKFISPDQLPVEFGGTMTDP- 307

  Fly   305 EPHPPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAAVKLDALVRALVSSDRAILCWKIYS 369
            :.:|..|....:  ...||..|:..|.:.|  ..:|.:|........|...:.....:|.|:..|
Human   308 DGNPKCLTKINY--GGEVPKSYYLCEQVRL--QYEHTRSVGRGSSLQVENEILFPGCVLRWQFAS 368

  Fly   370 ------------TKFNRPQ----MVVLLPRLADDTH-----------PATLYML--EVSYTSQHH 405
                        ||....|    |..:||....:.|           .|.:|:|  :.:|:..|
Human   369 DGGDIGFGVFLKTKMGEQQSAREMTEVLPSQRYNAHMVPEDGSLTCLQAGVYVLRFDNTYSRMH- 432

  Fly   406 FWDFPALRTTKTECSEEQLNAIDQLIDSTDLECTLRDTQQPRP 448
                 |.:.:.|         ::.|:.....|.||:..:..||
Human   433 -----AKKLSYT---------VEVLLPDKASEETLQSLKAMRP 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	36/195 (18%)
		KU80	221..524	CDD:238445	53/294 (18%)
		Ku_PK_bind	562..663	CDD:285938
SEC14L4	XP_016884276.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900