Protein Alignment Ku80 and XRCC6

DIOPT Version :9

• Sequence 1: NP_609767.2
• Gene: Ku80 / 34930
• FlyBaseID: FBgn0041627
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001275905.1
• Gene: XRCC6 / 2547
• HGNCID: 4055
• Length: 609
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 114/608 - (18%)
• Similarity: 214/608 - (35%)
• Gaps: 135/608 - (22%)

  Fly     3 SNKECLIIVLDVRTCAAE---EVKL----KSAKCVAEILKDKIVCDRKDYVSFVLVGCDTDEIKT 60
            |.::.||.::|......|   |.:|    .|.:|:..:...||:...:|.::.|..|.:.|:
Human    33 SGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDK--- 94

  Fly    61 EDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALELQNVA---------TTL 116
            ...:..|:....|......:.:||..||..:...:..:.:.|..:...|..|.         ...
Human    95 NSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQF 159

  Fly   117 RVARRRILLLFDFNDFPQDYE---------KFNEITDELLGENIELI----VGTHNIAYIDNAIT 168
            :::.:|| :||...|.|...:         |..::.|  .|..::|:    .|..:|:.....|.
Human   160 KMSHKRI-MLFTNEDNPHGNDSAKASRARTKAGDLRD--TGIFLDLMHLKKPGGFDISLFYRDII 221

  Fly   169 S------------QPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRP 221
            |            :...:.:..||....|  .:|.|||.:
Human   222 SIAEDEDLRVHFEESSKLEDLLRKVRAKE--TRKRALSRL------------------------- 259

  Fly   222 WVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIVIRETRHYIKGTEITPLPENLITG 286
               ..|||....||:.:..::....:.|.  :|::.|.:|.|..:||.:...|....||.:....
Human   260 ---KLKLNKDIVISVGIYNLVQKALKPPP--IKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRS 319

  Fly   287 YMLGGTPVPYDEAVLEPKEPH------PPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAA 345
            .:.|...:     :||.:|..      .|||...||.....:...::...||::...:.....::
Human   320 QIYGSRQI-----ILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSS 379

  Fly   346 VKLDALVRALVSSDRAILCWKIYSTKFN-RPQMVVLLPR---LAD---DTHPATLYMLEVSYTSQ 403
            ....||:...:..:.|.||  .|:.:.| .|..|.|:|:   |.|   ...|....::.:.:...
Human   380 TLFSALLIKCLEKEVAALC--RYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADD 442

  Fly   404 HHFWDFPALRTTKTECSEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNV 468
            .....|    |.|...:.||:..:..:::.  |..|.|......|..|......:||       .
Human   443 KRKMPF----TEKIMATPEQVGKMKAIVEK--LRFTYRSDSFENPVLQQHFRNLEAL-------A 494

  Fly   469 MDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEEKSKRAAAIVKKLFPLRYSRAWQ-EKLLA 532
            :|::|.:...|                 ..:| .:|..:||..::|.:...|.|...:. |..:.
Human   495 LDLMEPEQAVD-----------------LTLP-KVEAMNKRLGSLVDEFKELVYPPDYNPEGKVT 541

  Fly   533 KEQAEN----GVAVKSEPAEKEI 551
            |.:.:|    ....|.|.:|:|:
Human   542 KRKHDNEGSGSKRPKVEYSEEEL 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	44/246 (18%)
		KU80	221..524	CDD:238445	62/315 (20%)
		Ku_PK_bind	562..663	CDD:285938
XRCC6	NP_001275905.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		ku70	26..608	CDD:273151	114/608 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..562		5/25 (20%)
		Interaction with DEAF1. /evidence=ECO:0000269|PubMed:22442688	550..609		4/15 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000