DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ku80 and Xrcc5

DIOPT Version :9

Sequence 1:NP_609767.2 Gene:Ku80 / 34930 FlyBaseID:FBgn0041627 Length:699 Species:Drosophila melanogaster
Sequence 2:XP_006495955.1 Gene:Xrcc5 / 22596 MGIID:104517 Length:748 Species:Mus musculus


Alignment Length:772 Identity:186/772 - (24%)
Similarity:309/772 - (40%) Gaps:176/772 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ASNKECLIIVLDV-----RTCAAEEVKLKSAKCVAEI-LKDKIVCDRKDYVSFVLVGCD-TDEIK 59
            :.||..:::.:||     .:...||..::.||.|..: ::.::..:.||.::.||.|.| ||...
Mouse     4 SGNKAAVVLCVDVGVAMGNSFPGEESPIEQAKKVMTMFVQRQVFSESKDEIALVLYGTDGTDNAL 68

  Fly    60 TEDASHPNVLPFGEPRLCSWQLLLEFFQFV----NK--TACEDGEWLNGLQAALEL-QNVATTLR 117
            .....:.|:      .:|. .|:|..|..:    ||  .:.:..::|:.|...::| |......:
Mouse    69 AGKDQYQNI------TVCR-HLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKK 126

  Fly   118 VARRRILLLFDFND-FPQD-----------------------YEKFNEITDELLGENIELIVGTH 158
            ..::.|.:..|.:. |.||                       .:|..|     .||..:|..|  
Mouse   127 FGKKHIEVFTDLSSPFSQDQLDVIICNLKKSGISLQFFLPFPIDKNGE-----PGERGDLDSG-- 184

  Fly   159 NIAYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATL---------CSFKEALH--T 212
                :|:...|.||.        |..|  .||..:.:|.|...:|         .||.|:|.  .
Mouse   185 ----LDHLKPSFPQK--------GLTE--QQKEGIRMVTRVMLSLEGEDGLDEIYSFSESLRQLC 235

  Fly   213 VFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAE------KDEIVIRETRHYI 271
            |||...||...|..:|.||..:||.   |:|.|:....|..|.|..      |.|.:.:||.:.:
Mouse   236 VFKKIERRSMPWPCQLTIGPNLSIK---IVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCL 297

  Fly   272 KGTEITPL-PENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLY 333
            ...:.|.: .|:.|.||..|...:|:.:...|..:....|..|  .||.|.:.|...:|.|..:.
Mouse   298 NDDDETEVSKEDTIQGYRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVL 362

  Fly   334 LLVHQKHNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEV 398
            .:...|.:::|||.|.:||.||...:...:....|..:.| ||:.|..|.: .|.:...:| :::
Mouse   363 KVFAAKDDEAAAVALSSLVHALDELNMVAIVRYAYDKRSN-PQVGVAFPYI-KDAYECLVY-VQL 424

  Fly   399 SYTSQHHFWDFPALRTTKTEC--SEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALP 461
            .:......:.|.:|:..| :|  :|.||:|||.||||..|   ::..::..  ...||.|...:|
Mouse   425 PFMEDLRQYMFSSLKNNK-KCTPTEAQLSAIDDLIDSMSL---VKKNEEED--IVEDLFPTSKIP 483

  Fly   462 SIFEQNVMDILERKVIYDNDK----EDKMLKDKNFADVFWRVPDPLEEKSKRAAAI--VKKLFPL 520
            :...|.:...|..:.::..::    :..:|   |..|      .|.|.|:|..:.:  ||.||||
Mouse   484 NPEFQRLYQCLLHRALHLQERLPPIQQHIL---NMLD------PPTEMKAKCESPLSKVKTLFPL 539

  Fly   521 RYSRAWQEKLLAKEQA----------ENGVAVKSEPAEKE-----IPLPSDG----VGLIDPISD 566
                  .|.:..|.|.          |.|.|.|....|||     |...::|    ||.::|:.:
Mouse   540 ------TEVIKKKNQVTAQDVFQDNHEEGPAAKKYKTEKEEDHISISSLAEGNITKVGSVNPVEN 598

  Fly   567 F----RRVLASVHTISNATERDARFQALAADTRVVIITLLQRRKQNIGQLGELI----TLY---- 619
            |    |:.:||.       |.|.:.:|....|:..:.|.||.    |..:.:.:    |||    
Mouse   599 FRFLVRQKIASF-------EEDCKPKAKNTLTQEEVATSLQL----ISHIEQFLDTNETLYFMKS 652

  Fly   620 -------RQSCIDFNTFLEYDKFAEELKKIALAKNRSEFWQDVMVD------KQLGP 663
                   |:..|.|:....::.|.|.|::....|..:.||:.|:.|      |..||
Mouse   653 MDCIKAFREEAIQFSEEQRFNSFLEALREKVEIKQLNHFWEIVVQDGVTLITKDEGP 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ku80NP_609767.2 Ku_N 7..213 CDD:281693 52/254 (20%)
KU80 221..524 CDD:238445 83/319 (26%)
Ku_PK_bind 562..663 CDD:285938 28/125 (22%)
Xrcc5XP_006495955.1 Ku_N 9..244 CDD:367627 56/262 (21%)
KU80 244..542 CDD:238445 83/324 (26%)
Ku_PK_bind 594..722 CDD:370122 30/127 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837726
Domainoid 1 1.000 50 1.000 Domainoid score I11681
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 102 1.000 Inparanoid score I4959
Isobase 1 0.950 - 0 Normalized mean entropy S8037
OMA 1 1.010 - - QHG53888
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003754
OrthoInspector 1 1.000 - - oto94120
orthoMCL 1 0.900 - - OOG6_102536
Panther 1 1.100 - - LDO PTHR12604
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R647
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.840

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