Protein Alignment Ku80 and Xrcc5

DIOPT Version :10

• Sequence 1: NP_609767.2
• Gene: Ku80 / 34930
• FlyBaseID: FBgn0041627
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: XP_006495955.1
• Gene: Xrcc5 / 22596
• MGIID: 104517
• Length: 748
• Species: Mus musculus
• Alignment Length: 772
• Identity: 186/772 - (24%)
• Similarity: 309/772 - (40%)
• Gaps: 176/772 - (22%)

  Fly     2 ASNKECLIIVLDV-----RTCAAEEVKLKSAKCVAEI-LKDKIVCDRKDYVSFVLVGCD-TDEIK 59
            :.||..:::.:||     .:...||..::.||.|..: ::.::..:.||.::.||.|.| ||...
Mouse     4 SGNKAAVVLCVDVGVAMGNSFPGEESPIEQAKKVMTMFVQRQVFSESKDEIALVLYGTDGTDNAL 68

  Fly    60 TEDASHPNVLPFGEPRLCSWQLLLEFFQFV----NK--TACEDGEWLNGLQAALEL-QNVATTLR 117
            .....:.|:      .:|. .|:|..|..:    ||  .:.:..::|:.|...::| |......:
Mouse    69 AGKDQYQNI------TVCR-HLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKK 126

  Fly   118 VARRRILLLFDFND-FPQD-----------------------YEKFNEITDELLGENIELIVGTH 158
            ..::.|.:..|.:. |.||                       .:|..|     .||..:|..|
Mouse   127 FGKKHIEVFTDLSSPFSQDQLDVIICNLKKSGISLQFFLPFPIDKNGE-----PGERGDLDSG-- 184

  Fly   159 NIAYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATL---------CSFKEALH--T 212
                :|:...|.||.        |..|  .||..:.:|.|...:|         .||.|:|.  .
Mouse   185 ----LDHLKPSFPQK--------GLTE--QQKEGIRMVTRVMLSLEGEDGLDEIYSFSESLRQLC 235

  Fly   213 VFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAE------KDEIVIRETRHYI 271
            |||...||...|..:|.||..:||.   |:|.|:....|..|.|..      |.|.:.:||.:.:
Mouse   236 VFKKIERRSMPWPCQLTIGPNLSIK---IVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCL 297

  Fly   272 KGTEITPL-PENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLY 333
            ...:.|.: .|:.|.||..|...:|:.:...|..:....|..|  .||.|.:.|...:|.|..:.
Mouse   298 NDDDETEVSKEDTIQGYRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVL 362

  Fly   334 LLVHQKHNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEV 398
            .:...|.:::|||.|.:||.||...:...:....|..:.| ||:.|..|.: .|.:...:| :::
Mouse   363 KVFAAKDDEAAAVALSSLVHALDELNMVAIVRYAYDKRSN-PQVGVAFPYI-KDAYECLVY-VQL 424

  Fly   399 SYTSQHHFWDFPALRTTKTEC--SEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALP 461
            .:......:.|.:|:..| :|  :|.||:|||.||||..|   ::..::..  ...||.|...:|
Mouse   425 PFMEDLRQYMFSSLKNNK-KCTPTEAQLSAIDDLIDSMSL---VKKNEEED--IVEDLFPTSKIP 483

  Fly   462 SIFEQNVMDILERKVIYDNDK----EDKMLKDKNFADVFWRVPDPLEEKSKRAAAI--VKKLFPL 520
            :...|.:...|..:.::..::    :..:|   |..|      .|.|.|:|..:.:  ||.||||
Mouse   484 NPEFQRLYQCLLHRALHLQERLPPIQQHIL---NMLD------PPTEMKAKCESPLSKVKTLFPL 539

  Fly   521 RYSRAWQEKLLAKEQA----------ENGVAVKSEPAEKE-----IPLPSDG----VGLIDPISD 566
                  .|.:..|.|.          |.|.|.|....|||     |...::|    ||.::|:.:
Mouse   540 ------TEVIKKKNQVTAQDVFQDNHEEGPAAKKYKTEKEEDHISISSLAEGNITKVGSVNPVEN 598

  Fly   567 F----RRVLASVHTISNATERDARFQALAADTRVVIITLLQRRKQNIGQLGELI----TLY---- 619
            |    |:.:||.       |.|.:.:|....|:..:.|.||.    |..:.:.:    |||
Mouse   599 FRFLVRQKIASF-------EEDCKPKAKNTLTQEEVATSLQL----ISHIEQFLDTNETLYFMKS 652

  Fly   620 -------RQSCIDFNTFLEYDKFAEELKKIALAKNRSEFWQDVMVD------KQLGP 663
                   |:..|.|:....::.|.|.|::....|..:.||:.|:.|      |..||
Mouse   653 MDCIKAFREEAIQFSEEQRFNSFLEALREKVEIKQLNHFWEIVVQDGVTLITKDEGP 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:427470	52/254 (20%)
		KU80	221..524	CDD:238445	83/319 (26%)
		Ku_PK_bind	562..>659	CDD:462604	27/121 (22%)
Xrcc5	XP_006495955.1	Ku_N	9..244	CDD:427470	56/262 (21%)
		KU80	244..542	CDD:238445	83/324 (26%)
		Ku_PK_bind	594..723	CDD:462604	30/127 (24%)