DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and Clvs2

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_780657.1	Gene:	Clvs2 / 215890	MGIID:	2443223	Length:	327	Species:	Mus musculus

Alignment Length:	273	Identity:	60/273 - (21%)
Similarity:	92/273 - (33%)	Gaps:	99/273 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 KEPHPPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAAVKLDALVRALVSSDRA------- 361
            |:..|.||         |..|.|  |..:.:|.....:||....:| ::||::.|..|
Mouse   101 KDGFPGGL---------ANLDHY--GRKILVLFAANWDQSRYTLVD-ILRAILLSLEAMIEDPEL 153

  Fly   362 -------ILCWKIYSTKFNRPQMVVLLP---RLA----DDTHPATLYMLEVSYTSQHHF----WD 408
                   |:.|..::.|    |...|.|   |||    .|:.||....:        ||    |.
Mouse   154 QVNGFVLIIDWSNFTFK----QASKLTPNMLRLAIEGLQDSFPARFGGI--------HFVNQPWY 206

  Fly   409 FPALRTTKTECSEEQ-----------LNAIDQLIDSTDLECTLRDTQQP---RPWAQNDLLPFDA 459
            ..||.|......:|:           ||::.|||....|.........|   ..||:.
Mouse   207 IHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWART------- 264

  Fly   460 LPSIFEQNVMDILERKVIYDNDKE------DKMLKDKNFADVFWRVPDPLEEKS-KRAAAIVKKL 517
                       :|:.:  ||:|.|      :..:||         |...|..|| ||:.::|...
Mouse   265 -----------LLDHE--YDDDSEYNVDSYNMPVKD---------VDKELSPKSMKRSQSVVDPT 307

  Fly   518 FPLRYSRAWQEKL 530
            ...|..::.:|.:
Mouse   308 ALKRMDKSEEENM 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693
		KU80	221..524	CDD:238445	59/265 (22%)
		Ku_PK_bind	562..663	CDD:285938
Clvs2	NP_780657.1	CRAL_TRIO_N	29..75	CDD:215024
		SEC14	106..251	CDD:238099	39/168 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..327		8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900