Protein Alignment Ku80 and cku-80

DIOPT Version :9

• Sequence 1: NP_609767.2
• Gene: Ku80 / 34930
• FlyBaseID: FBgn0041627
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001309438.1
• Gene: cku-80 / 175578
• WormBaseID: WBGene00000520
• Length: 713
• Species: Caenorhabditis elegans
• Alignment Length: 633
• Identity: 129/633 - (20%)
• Similarity: 234/633 - (36%)
• Gaps: 182/633 - (28%)

  Fly   140 NEITDELLGENIELIVGTHNIAYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATL- 203
            |.:.:.:..||.:|:|...:.:..|..|             .|.||  |.:|..|.|.....||
 Worm   144 NGLNENIRQENFDLLVEAVSESNADLMI-------------IGIDE--NPEYPASRVAELAETLE 193

  Fly   204 ---CSFKEA--LHTVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVK---VWAEKD 260
               .:|:..  :.:.|:...:....:|...:|..  .|.|..|.|:|::....|:|   ..:|.:
 Worm   194 GRTYTFQNVAKMLSTFQARQKSERKYNKMWDIAP--GIHLPVIFALKSEKSTALLKFKNADSEGN 256

  Fly   261 EIVIRETRHYIKGTEITPLP--------------------ENLIT--GYMLGGTPVPYDEAVLEP 303
            |:|..|..| ::..|:.|..                    ||:.|  ||..|.:.:..|...|:.
 Worm   257 EMVRLEQMH-VETDEVAPKDEFKSPVLEEKPKFQKNFKPVENIKTMHGYNFGKSVIMMDPEYLKE 320

  Fly   304 K-------EPHPPG-LHFFGFIKRNAVPDEYFCGESLYLLVHQKHN-QSAAVKLD-ALVRALVSS 358
            |       |....| |....|.||..:.|.|....|...::...:: :|.|.|.. :|:.|::|.
 Worm   321 KYNDHNFNEGQTGGVLKLIQFTKRANILDSYLLDASAKTVLPALNSPKSGATKATVSLIEAMLSL 385

  Fly   359 DRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHFWDFPALRTTKTECSEE- 422
            ..|.:|...:..| :..|::.|||...::|....|..:::.::.     |...|:..|....||
 Worm   386 RVAAICRYTFHAK-SHVQLIALLPHQDEETGVFYLRSVKLPFSD-----DMRTLKFPKFSFDEED 444

  Fly   423 ---------QLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNVMD-------- 470
                     ||:|:|.|||...|:                   .|.:.|:.|..:.|
 Worm   445 EDLNKPTVAQLSAVDDLIDCMQLQ-------------------EDEISSLVEGGMSDPKLQMQCH 490

  Fly   471 ILERKVIYDNDK-----------EDKMLKDK-----NFADVFWRVP-----DPLEEKSKRAAAIV 514
            .|:..|::.||.           .|:::..|     ...::|.::.     .|: :|:||....|
 Worm   491 FLKSLVLHPNDTFENHSNRTNQILDQIMAPKRRVEAEHPEIFQKLGREFNLQPI-QKTKRERVTV 554

  Fly   515 KKLFPLRYSRAWQEK---LLAKEQAENGVAVK----------SEPAEKEIPLPSDGVGLIDPISD 566
            :..........|.||   :...::.::|.:.|          :...|.::.:..||        .
 Worm   555 EPEDLQTMISEWTEKKQNMTQPDEVDDGASQKKKKKPNAKKLTRKEEVQMDIMEDG--------G 611

  Fly   567 FRRVLASV-HTISNATERDARFQALAADTRVVIITLLQRRKQNIGQLGELITLY--RQSCIDFNT 628
            ..||.:.: ..|||.    .:||...|.|.  ..|||      :.:|..:.:::  ...|.:||.
 Worm   612 ASRVCSKILEMISNT----CKFQPNGAVTE--FFTLL------VNELNVIRSVFVENSKCDEFNE 664

  Fly   629 FL-------EYDKFAEEL-----------KKIALAK----NRSEFWQD 654
            .|       :::.|||.|           .::::::    |.:|||::
 Worm   665 LLKKLKDEEDFEPFAEVLSEEKSCNPIDSSEVSMSEVSVANAAEFWEE 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	17/78 (22%)
		KU80	221..524	CDD:238445	78/376 (21%)
		Ku_PK_bind	562..663	CDD:285938	25/118 (21%)
cku-80	NP_001309438.1	vWFA	12..178	CDD:238119	10/48 (21%)
		KU80	229..542	CDD:238445	71/338 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8037
OMA	1	1.010	-	-		QHG53888
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003754
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102536
Panther	1	1.100	-	-	LDO	PTHR12604
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R647
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830