DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ku80 and xrcc5

DIOPT Version :9

Sequence 1:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_002942054.3	Gene:	xrcc5 / 100493415	XenbaseID:	XB-GENE-996225	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	175/782 - (22%)
Similarity:	308/782 - (39%)	Gaps:	153/782 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KECLIIVLDV-----RTCAAEEVKLKSAKCVAEI-LKDKIVCDRKDYVSFVLVGCD-TDEIKTED 62
            |..:::.:||     .:...||...:.||.|..: |:.::..:.||.::.||.|.| ||......
Frog     6 KSAVVLCMDVGLAMSHSNQGEESPFEQAKKVMMLFLQRQVFAESKDEIAVVLFGTDTTDNALARG 70

  Fly    63 ASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALELQNVATTLRVARRRILLLF 127
            ..:.|:.......|..:. |||..|.|.:......::|:.|..:::|....|
Frog    71 DQYENISVHRHLMLPDFD-LLEQIQNVVEPGSTQADFLDALIVSMDLLQKET------------- 121

  Fly   128 DFNDFPQDYEK-----FNEITDELLGENIELIVGTHNIAYIDNAITSQPQAIFNFSRKCGPDELN 187
                ..:.||:     |::::.....:.:|:|:.....|    .|:.|....|....:...|..|
Frog   122 ----LGKKYERLHIAVFSDLSSPFSVDQLEVIIANLKKA----GISLQFFLPFPVDEEEAGDSSN 178

  Fly   188 N--------------------QKYALSLVPRCNATL---------CSFKEALH--TVFKVTNRRP 221
            |                    ||..:.:|.:...:|         .:|:|:|.  ::||...|||
Frog   179 NRGDSGSSDRGRGPGKGLSDQQKEGIEMVRKIMFSLDGEDGLSEVFTFRESLERLSIFKKIERRP 243

  Fly   222 WVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWA------EKDEIVIRETRHYIKGTEITPL- 279
            ..|..:|.|||.:||.   |:..|:.|..|:.|.||      .|.|.:.:||.:.:...|.|.:
Frog   244 MAWPCQLTIGSGLSIR---IVGYKSVTEEKVKKTWAHVDAKSNKKEDIKKETVYCLNNDEETEVE 305

  Fly   280 PENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHF--FGFIKRNAVPDEYFCGESLYLLVHQKHNQ 342
            .|:.|.||..|...||:.:...|..:....|..|  .||.|.:.||...|.|..:..:.....::
Frog   306 KEDTIQGYRYGSDIVPFSKVDQEQMKYRSEGKCFAVLGFTKSSLVPSHQFVGNQVVKIFAPSDDE 370

  Fly   343 SAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHFW 407
            :|:|.|.:|:.||...|...:...:|..:.| ||:.|..||:.|.........|......:.|.
Frog   371 AASVALSSLIHALDEMDMVAIVRYVYDRRCN-PQVGVAFPRIKDKYECLVYIQLPFMEDLRQHL- 433

  Fly   408 DFPALRTTKT-ECSEEQLNAIDQLIDSTDL--------ECTLRDTQQPRPWAQ--------NDLL 455
             |.:|:.:|. ..::.||:|:|.||.|..|        |...:.::.|.|..|        ..|.
Frog   434 -FSSLKNSKKFTPTDSQLSAMDSLIGSMSLVSDDGETTEDLFKPSKIPNPQFQRLFQCLQHKALN 497

  Fly   456 PFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEEKSKRAAAIVKKLFPL 520
            |..:||.| |:::.|:||                         .|..:.|..:.:.|.||..|||
Frog   498 PESSLPPI-EKHLQDMLE-------------------------APGAVTEGCRASLATVKACFPL 536

  Fly   521 RYSRAWQE-----KLLAKEQAENGVAVKSEPAEKEIPLPS------DGVGLIDPISDFRRVLASV 574
            :.:...:|     ::..|:..:...|.|.:..:::..|..      ..||.::|..|||.:|
Frog   537 QEATKRKEVKTGDEIFTKKTEDEPDAKKLKEDDEDFSLSRLVDENITVVGSVNPDQDFRALL--- 598

  Fly   575 HTISNATERDARFQALAADTRVVIITLLQ-RRKQNIGQLGELITLYRQSCIDFNTFLEYDKFAEE 638
                  .::::.|:.::......|:..|. ::.|...:....|..:|:..|..:....:::|.:.
Frog   599 ------RQKNSDFKHVSEQLIKRILECLDVKQYQYYMKSIRCIKAFREEAIKSSHVQNFNEFLQM 657

  Fly   639 LKKIALAKNRSEFWQDVMVDKQLGPLVLGE---PTLDDELALKAYYTIENWVESGA-----NDME 695
            ||..|.:....||| |::|...:..:...|   .::..|.|.|.....|...|..|     .|::
Frog   658 LKLKAESSALMEFW-DIIVQDDISLITSSESKGSSVTPEEARKFLARKEEKAEEAAMMEEEGDVD 721

  Fly   696 DV 697
            |:
Frog   722 DL 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	46/248 (19%)
		KU80	221..524	CDD:238445	87/328 (27%)
		Ku_PK_bind	562..663	CDD:285938	21/101 (21%)
xrcc5	XP_002942054.3	Ku_N	8..243	CDD:397685	49/256 (19%)
		KU80	243..539	CDD:238445	87/327 (27%)
		Ku_PK_bind	589..701	CDD:400921	25/121 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10031
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4635
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185892at33208
OrthoFinder	1	1.000	-	-		FOG0003754
OrthoInspector	1	1.000	-	-		oto104328
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060