DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3793 and lcmt2

DIOPT Version :9

Sequence 1:	NP_001246038.1	Gene:	CG3793 / 34928	FlyBaseID:	FBgn0028507	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001122029.1	Gene:	lcmt2 / 100005300	ZFINID:	ZDB-GENE-110714-2	Length:	673	Species:	Danio rerio

Alignment Length:	305	Identity:	110/305 - (36%)
Similarity:	160/305 - (52%)	Gaps:	8/305 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DEAVIATNDDASDCKRCAVRLGYWKDDYIGYFVRNQERKAPEINRGYFARVKGVEMCVEKFLKKT 84
            |.||..|||.:...|..|...||:.||::.:||....|:||.|||||:.|.|.|:.||::||..|
Zfish    12 DAAVQGTNDSSVVSKVSAAAQGYFHDDFLKHFVCKMSRRAPLINRGYYVRWKAVDHCVKQFLHAT 76

  Fly    85 SGNC---QIINLGCGFDTLYFRLR-DTAHQVKNFIELDFPTVTARKCYTIKRNKALLARIHDEDG 145
            . :|   ||::||.|||:|:|||| :.|.......|:|||.|..||...|..|..|...:.|.:.
Zfish    77 K-SCSRRQILSLGAGFDSLFFRLRAEGALGGVTVFEVDFPEVARRKAALINSNACLKDLLPDWET 140

  Fly   146 EV--RLSPTDLHGPSYHLMGVDLRNLDEVDSKLQQAEVDYSLPTIFLAECVLVYIEAQNCRNLLK 208
            .:  :.:...:....|:|:|.|:|...||::.|..|.:.:..||:.|:|.||.|:|.|....::.
Zfish   141 VLNKQTNAVFISSGHYNLIGADVRKEQEVEASLSAAGLQWDNPTLILSEVVLTYMETQWSDAVIG 205

  Fly   209 WIAQKFQAAVFVNYEQVNMNDRFGDVMLNNLRGRGCSLAGVESCLSLDTQRNRFKDSGWTGARAW 273
            |.|:....::||.|||::.:|.||.||.::.......:..::.......|..||...||......
Zfish   206 WAARLLPQSMFVMYEQIHPDDPFGRVMQSHFLKLNSKIHSLQQYPDNVAQTQRFIQEGWEKCHCL 270

  Fly   274 DMVQVY-ESISAAERQRIERLEMLDEGELLLQLFQHYCLVVAWLG 317
            ||.|.| :.:...||||||.||..||.|...|...||.::.|..|
Zfish   271 DMNQFYFDLLPEDERQRIENLEPFDEFEEWHQKCSHYFILTASKG 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3793	NP_001246038.1	LCM	22..211	CDD:397957	73/194 (38%)
lcmt2	NP_001122029.1	LCM	28..208	CDD:281992	67/180 (37%)
		Kelch_4	465..512	CDD:290154
		KELCH repeat	466..517	CDD:276965
		KELCH repeat	521..570	CDD:276965
		Kelch_3	530..578	CDD:290151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2918
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094856at2759
OrthoFinder	1	1.000	-	-		FOG0001575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100931
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2177
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750