DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Ces2f

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	592	Identity:	171/592 - (28%)
Similarity:	257/592 - (43%)	Gaps:	114/592 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 TNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQ 203
            |:.|||:|..|::.|                 :......|||||:|.||....||.||.....|.
Mouse    38 THTGQVRGKFVHLTD-----------------IKAGAHNFLGIPFAKPPVGPLRFAPPEAPEPWS 85

  Fly   204 LLQAVDFGPA-CPQP---VRYTG--ATKGIM---DMDEDCLYLNVYSPKTGAGVAQKYPVMVYIH 259
            .::.....|| |.|.   |...|  ..|.|:   .|.|||||||:|:| ..|......||||::|
Mouse    86 GVRDGTSQPAMCLQNDDIVNLEGLKIIKMILPPFSMSEDCLYLNIYTP-AHAQEGSNLPVMVWLH 149

  Fly   260 GGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNI 324
            ||..:.|.::::.|.:||:..|||||...||||..||.|||||.:.||:|.|||..||.||..||
Mouse   150 GGGLVAGMASMYDGSVLAATEDVVVVVTQYRLGIPGFYSTGDEQARGNWGFLDQTAALHWVQQNI 214

  Fly   325 EFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVL 389
            ..|.|:.:|:||||..|||.|....:::|.::.:..|.|.:||.||.. .:|.|......|.  :
Mouse   215 ANFGGNPDSVTLFGQSAGGTSVSFHVLSPVSQGLFHRAIMESGVALLP-TIIPDSPEMIFTK--V 276

  Fly   390 GQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDW 454
            ..|.||...:|..||.||| |:|     .||......:|.:.|.:                 .|.
Mouse   277 ANLSGCETSNSEALVRCLR-GKS-----EAEILAMSKAFRFMPAV-----------------VDG 318

  Fly   455 RFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNY 519
            :||.:.|:.|:.:..|: .:..:.||...|..:.:.:                      :|:::.
Mouse   319 KFLPRHPKKLLASADFH-PVPSIIGVNNDEYGWIIPK----------------------IFKFSQ 360

  Fly   520 T---LNPNGVYEAIKYIYT----------------FWPDPNNNTIIRDQYINMLSDLYYRAPVDQ 565
            |   :|.|.: :||..|.|                :..|..:...::.|:..|:.|.....|..|
Mouse   361 TIRKINRNNL-KAIMKITTEQMMLPSECGDLLIEEYLRDTEDPWTLQMQFREMIGDFLIIIPALQ 424

  Fly   566 MVKLMLEQKVPVYMYVLNTTVEALNL--PQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMW 628
            :.:.. ....|||.|........|..  |...|..|..|.|.:.|:.|...:|          .:
Mouse   425 VARFQ-RSHAPVYFYEFQHRSSLLKYFRPWHVKADHGDELYLIFGSFFWGLKF----------SF 478

  Fly   629 TDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECA 693
            |..::.:|...|:.:.||||||||..:.:  .::..:.|.:: ||.::...:....|..|:  ..
Mouse   479 TAEEKLLSRKMMKYWANFARYGNPNSEDL--PYWPASNQDDL-YLQLDIHPSVGHALKARR--LP 538

  Fly   694 FWTQYLP 700
            |||:.||
Mouse   539 FWTKTLP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	166/585 (28%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	166/585 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740