DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Ces1a

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	179/606 - (29%)
Similarity:	272/606 - (44%)	Gaps:	131/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|..|:|.|..:.:      :.|.:|           .:||||:|:|.||....||.||:....
  Rat    26 VDTLQGKVLGKYISL------EGFTQP-----------VAVFLGVPFAKPPLGSLRFAPPQPAES 73

  Fly   202 WQLLQ-AVDFGPACPQ-----PVR---YTGATKGI-MDMDEDCLYLNVYSPKTGAGVAQKYPVMV 256
            |..:: |..:.|.|.|     ||.   :|...:.: ::..|||||||:||| |......:.||||
  Rat    74 WSFVKNATSYPPMCSQITGVGPVLSEVFTNQLENVPLEYSEDCLYLNIYSP-TDLTSKDRLPVMV 137

  Fly   257 YIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVY 321
            ::|||..:.|.::.|.|..|::...||||.:.||||..||||||||:|.||:|..||..||:||.
  Rat   138 WVHGGGLLSGGASTFDGLALSTHEKVVVVVIQYRLGIWGFLSTGDEHSRGNWGHFDQVAALQWVQ 202

  Fly   322 DNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTS 386
            :||..|.||.||:||||..|||.|..:|:::|.|:|:..|.|::||.||.....      .:||.
  Rat   203 NNIVNFGGDPNSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLF------RENTR 261

  Fly   387 RVLGQL---LGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNF---TLPGDDW 445
            ....|:   .||:..:|..:|.|||. ::..||             ....|...|   .|.||.
  Rat   262 LAAEQVAIATGCAATTSADIVRCLRE-KTEEEL-------------LATTLKMKFFALDLHGDP- 311

  Fly   446 YEGWREKDWRFLT---------QTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYEL 501
                 .:.:.|||         :.||.::....|| .:.|:.|:..||..:|:.....    |.|
  Rat   312 -----RESYPFLTTVIDGVLLPKAPEEILSEKNFN-TVPYIVGINKQEFGWFIPTMMG----YPL 366

  Fly   502 DGRFFDQKIREHVFRYNYTLNPNGVYEAI------KYI-YTFWPDPNNNTIIRDQYINMLSDLYY 559
            .....|||....:...:|.|  ..:.:.:      ||: .:..||..     :|.:::|:.|:.:
  Rat   367 SESKLDQKTATSLLWKSYPL--TNISKELTPVATEKYLGGSDCPDKK-----KDLFLDMMGDVLF 424

  Fly   560 RAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYP--------------HDIERYFLTGAP 610
            ..|...:.:...:.:...|:|            :::.:|              |..|.|.:.|.|
  Rat   425 AVPSVIVARYHRDARATTYVY------------EFKYHPSFVSDMRPKTVIADHGDEVYSVWGTP 477

  Fly   611 FMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNI 675
            |:       ||..     ::.:.|:|...|:.:.||||.|||..:   |:.....|..:..||.|
  Rat   478 FL-------KEGA-----SEEEINLSTMMMKFWGNFARNGNPNGE---GLPHWPEYDEKESYLQI 527

  Fly   676 NTTYNSSILLNYRQTECAFWT 696
            .||...:..|.|:  |.||||
  Rat   528 GTTIQQAQKLKYK--EVAFWT 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	176/603 (29%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	176/603 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740