DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and NLGN4X

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_005274621.1	Gene:	NLGN4X / 57502	HGNCID:	14287	Length:	836	Species:	Homo sapiens

Alignment Length:	893	Identity:	246/893 - (27%)
Similarity:	371/893 - (41%)	Gaps:	209/893 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.||||:::|.:     .|.|           :.::|....:||:|||.|||.|.||:||.....
Human    48 VNTNYGKIRGLR-----TPLP-----------NEILGPVEQYLGVPYASPPTGERRFQPPEPPSS 96

  Fly   202 WQ-LLQAVDFGPACPQ------------PVRYTGATKGIM----DMDEDCLYLNVYSP-KTGAGV 248
            |. :.....|...|||            |:.:|.....:|    |.:|||||||:|.| :.||..
Human    97 WTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANT 161

  Fly   249 AQ---------------------KYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLG 292
            .:                     |.|||||||||.::.|..|:..|.||||:.:|:|:|:|||||
Human   162 KKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 226

  Fly   293 ALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRN 357
            .||||||||:.:.||||:|||..||||:.:|:..|.||...:|:||.|||.:...||.::..:..
Human   227 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEG 291

  Fly   358 IVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFS 422
            :.::.|.|||:||:.||:   .|:....:|:|...:||::..:..:|.||| .:::.||.....:
Human   292 LFQKAIIQSGTALSSWAV---NYQPAKYTRILADKVGCNMLDTTDMVECLR-NKNYKELIQQTIT 352

  Fly   423 PQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAF 487
            |......:|||:|.: .:|.|                 |:.|:..|:| .|...|.||...|...
Human   353 PATYHIAFGPVIDGD-VIPDD-----------------PQILMEQGEF-LNYDIMLGVNQGEGLK 398

  Fly   488 FV---AQNESLSPYYELDG---RFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTI 545
            ||   ..||        ||   ..||..:...|.. |.|....:.:.|.||::||.|.|..|...
Human   399 FVDGIVDNE--------DGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPET 455

  Fly   546 IRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAP 610
            .|...:.:.:|..:.||......|..:...|.|.|......::...|.|....|..|..::.|.|
Human   456 RRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIP 520

  Fly   611 FM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIR 671
            .: .||.|...       ::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.
Human   521 MIGPTELFSCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVA 578

  Fly   672 YLNINTTYNSSILL------------NYRQTECAFWT-------------QYLPTVIGVLVP--- 708
            :    :.||....|            :||.|:.|||.             ||:.|...|..|
Human   579 W----SKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMT 639

  Fly   709 TYPPTT-----EYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSD--RFYDEDVFI 766
            ::|..|     :.|...|.|      :::.|               .|.|...|  :...||..:
Human   640 SFPYGTRRSPAKIWPTTKRP------AITPA---------------NNPKHSKDPHKTGPEDTTV 683

  Fly   767 NGEGLEPEQD-------TRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSP 824
            .   :|.::|       |..|..:.:..|..|..:   :|..:|....:|     |      |.|
Human   684 L---IETKRDYSTELSVTIAVGASLLFLNILAFAA---LYYKKDKRRHET-----H------RRP 731

  Fly   825 SSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASPP---------VEE 880
            |....|....:....:..:||:      :||.|......|.|...|.::..||         .::
Human   732 SPQRNTTNDIAHIQNEEIMSLQ------MKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDD 790

  Fly   881 KRLLQP--LSSTPVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTT 926
            ..|:.|  ::..|.|....:|   :.|..:.||...||. :|...|||
Human   791 IPLMTPNTITMIPNTLTGMQP---LHTFNTFSGGQNSTN-LPHGHSTT 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	190/619 (31%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	190/619 (31%)
NLGN4X	XP_005274621.1	Aes	<179..>286	CDD:223730	56/106 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920