Protein Alignment Gli and nlgn3b

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: XP_005165239.1
• Gene: nlgn3b / 567415
• ZFINID: ZDB-GENE-060526-197
• Length: 846
• Species: Danio rerio
• Alignment Length: 914
• Identity: 249/914 - (27%)
• Similarity: 365/914 - (39%)
• Gaps: 222/914 - (24%)

  Fly   130 TLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFK 194
            ||.....|.|..|:::|.:|                :.....:|....:||:|||.||..|.||.
Zfish    41 TLTYQPTVNTALGRLRGMRV----------------AVATEGLGPVDQYLGVPYAAPPVGEKRFM 89

  Fly   195 PPRVHRGWQ-LLQAVDFGPACPQPVRYTGATKGIM-------DMD----------EDCLYLNVYS 241
            ||.....|. :..|..|.|.|||.||  .|...||       :||          |||||:|:|.
Zfish    90 PPDAPSAWSGVRNATRFPPVCPQTVR--NAVPDIMMPVWATYNMDTVATYLQEQSEDCLYMNIYV 152

  Fly   242 P------KTGAGVA---------------QKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVV 285
            |      :||...|               ...|||::||||.::.|..|:..|.:|||:.:|:|:
Zfish   153 PTQSGTKRTGDMSADTERTEDDGLRDSRDDPRPVMLFIHGGSYMEGTGNIMDGSVLASYGNVIVI 217

  Fly   286 TLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLM 350
            |||||:|.||||||||:.:.||||:|||..||||:..||.:|.||...:|:||.|.|.:...||.
Zfish   218 TLNYRVGILGFLSTGDQAAKGNYGLLDQIQALRWINKNIGYFGGDPGRVTVFGSGIGASCVSLLT 282

  Fly   351 VAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYE 415
            ::..:..:..|.|.||||||:.|::   .|:....:|:|.:.:||::..:..||.|::. ||:.|
Zfish   283 LSHHSEGLFHRAIIQSGSALSSWSV---NYQPVKYTRLLAERVGCNVLDTQDLVLCMQK-RSYRE 343

  Fly   416 LGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGV 480
            |...|..|......:|||:|.:. :|.|                 ||.|:..|:| .|...|.||
Zfish   344 LVEQEIQPARFHVAFGPVIDGDL-IPDD-----------------PEVLMEQGEF-LNYDIMLGV 389

  Fly   481 TTQEAAFFVAQNESLSPYYE--LDGRFFDQKIREHV-FRYNYTLNPNGVYEAIKYIYTFWPDPNN 542
            ...|...||   |.:....|  :.|..||..:.:.| ..|.|....:.:.|.||::||.|.|.:|
Zfish   390 NQGEGFRFV---EGVVEPEEGGVSGSDFDFTVSDFVDSLYGYPEGKDTLRETIKFMYTDWADRDN 451

  Fly   543 NTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLT 607
            ....|...:.|.:|..:..|......|......|.:.|......::...|.|....|..|..::.
Zfish   452 PETRRKTLVAMFTDHQWVEPAVVTADLHARYGSPTFFYAFYHHCQSPMKPPWADSAHGDELPYVF 516

  Fly   608 GAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMH-----FQ 663
            |.|.: .||.||..       ::.||..:|...|..:||||:.|:   |.||....:|     |:
Zfish   517 GVPLIGPTELFPCN-------FSRNDIMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE 574

  Fly   664 R---AYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLP---------------TVIGVLVPTY 710
            .   |..|....|.::......:..:||.|:.|||...:|               |.:..|:.|:
Zfish   575 EVTWAKYGPHDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTRVPPLLTTH 639

  Fly   711 --------------------PPTTEYWWEPKEPLQIA-------FWSMSVA----CFFLIVLVVI 744
                                ||.:.   ....||.||       ..|:::|    ..||.|| ..
Zfish   640 SSHSATPRPGGNKARTSGKQPPQST---ARSGPLVIANPRDYSTELSVTIAVGASLLFLNVL-AF 700

  Fly   745 CCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVT-----NHHALRSRDNI-YEYRD 803
            ..:.:|..||.......:..        |::.|..:|..:..|     |...|...|.: .....
Zfish   701 AALYYRKDKRSRQDTPPQPA--------PQRQTPPIDLNYAPTSISGGNQEELSLCDPLRLTPAS 757

  Fly   804 SPSTKTLASKAHTDTTSLRSPSSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNG 868
            ||....|..:...|...|.:|||:|||..|.:..  .:.::|               ||.|
Zfish   758 SPRDYALTLRRSPDDIPLMTPSSVAMTPNSGTMT--PNTVTL---------------TPNS---- 801

  Fly   869 STAKVASPPVEEKRLLQPLSSTPVT------QLQAEPAKRVPTAASVSGSSRSTTPVPSARSTTT 927
                              ::.||.|      .|...|:.. |......|.:.:|.|.|
Zfish   802 ------------------VTMTPNTITMSPNSLMGYPSMH-PYNTFTHGYNSTTLPHP------- 840

  Fly   928 HTTT 931
            |:||
Zfish   841 HSTT 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	190/611 (31%)
		PRK13335	818..>918	CDD:139494	20/105 (19%)
nlgn3b	XP_005165239.1	COesterase	45..609	CDD:395084	190/614 (31%)
		Herpes_BLLF1	<753..>843	CDD:282904	27/136 (20%)