DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and ces2a

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001070720.1	Gene:	ces2a / 566132	ZFINID:	ZDB-GENE-061013-99	Length:	555	Species:	Danio rerio

Alignment Length:	605	Identity:	174/605 - (28%)
Similarity:	259/605 - (42%)	Gaps:	115/605 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 YGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQ-- 203
            :|.|:|..|....:|          :.|::       :||||:|.||....|...|:..:||:
Zfish    33 HGSVRGQYVKAKGSP----------AVVEQ-------YLGIPFAQPPVGPHRLAAPQPVQGWEGI 80

  Fly   204 ---------LLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIH 259
                     .||..|..||..:.:.......|:   .|||||||||:|...| .::|.|||::||
Zfish    81 RNATEHPLMCLQNPDILPAIAKAIDLEVTAIGV---SEDCLYLNVYTPSQRA-ESEKLPVMIWIH 141

  Fly   260 GGEFIRGASNLFQ------GHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALR 318
            ||....|.:.:|:      |..||::..||||.:.||||.||:.||||:::.||:|.|||..||:
Zfish   142 GGGLAMGGACMFKELCLYDGTPLAAYEKVVVVVIQYRLGILGYFSTGDQHAKGNWGFLDQIAALQ 206

  Fly   319 WVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQ 383
            ||..|||.|.||..|:|:.|..|||.||.||.::|.|:.:.:|.|.|||.|......::|   ..
Zfish   207 WVQQNIEAFGGDPQSVTIAGESAGGISASLLTLSPMTKGLFQRAIFQSGVATVKGYFVKD---PS 268

  Fly   384 NTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEF---SPQVGSFPWGPVLDHNFTLPGDDW 445
            ..::|:..:..|...||..||.|:|      |:...:.   :.:.|.||...|
Zfish   269 THAQVIANITECDFSSSEVLVKCIR------EMTEEQIIKAAQKKGIFPGAAV------------ 315

  Fly   446 YEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKI 510
                   |..|:...||.::::..|.: :..:.|.|..|..:.:.|  ...|...:.|  .|.|.
Zfish   316 -------DGEFIKAQPEEILKSKDFQK-VPILIGTTNHEFGWMLPQ--IFLPKEWVKG--MDTKA 368

  Fly   511 REHVFRYNYTLNPNGVYEAIKYIY-TFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQK 574
            .:....   .||.:|...|...|. .::.:......|||.:..:|.|::...|...:.....|..
Zfish   369 AKDRLG---LLNADGASGANGIIADEYFKNAKTPEEIRDAFTELLGDIFMVIPSITVASYHREAG 430

  Fly   575 VPVYMYVLNTTVEALN--LPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQ-RNMWTDNDRNMS 636
            ||||||.........|  .|.:.|..|..:..|:.||.|.|.       |:: ....|:.:..:.
Zfish   431 VPVYMYEFQHGPSTANKFRPSFVKADHADDVGFVFGACFWDV-------HVKGLGTLTEEENQLC 488

  Fly   637 HFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTE--------CA 693
            ...|:...||.|.|:|.|..|.    ...|....:|||          |..:|||        ..
Zfish   489 RTVMKYRANFIRTGSPNPAPVP----WPVYDQSNKYLN----------LGLQQTEGQDLKKDKLL 539

  Fly   694 FWTQYLPTVIGVLVPTYPPT 713
            |:|:.||..:..     |||
Zfish   540 FFTEELPKKLAA-----PPT 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	167/585 (29%)
ces2a	NP_001070720.1	COesterase	21..541	CDD:278561	167/585 (29%)
ces2a	NP_001070720.1	Aes	<122..346	CDD:223730	86/253 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830