Protein Alignment Gli and ces2b

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: XP_021326380.1
• Gene: ces2b / 561967
• ZFINID: ZDB-GENE-041014-96
• Length: 1611
• Species: Danio rerio
• Alignment Length: 958
• Identity: 244/958 - (25%)
• Similarity: 379/958 - (39%)
• Gaps: 262/958 - (27%)

  Fly    65 YGHY----QPNGYG-ANYPGRNPPGQYPQ-GMPNEDRFRFDPNDPNARTQFPGVLAGWREDLQGK 123
            :|::    .|||.| .::|......:|.. |:           ||.|.|           ||:||
Zfish   493 WGNFAHTGNPNGPGLTSWPEFGDEAEYLSIGL-----------DPKAST-----------DLKGK 535

  Fly   124 ------QRRDSLTLER--DVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSV--- 177
                  |....:..||  ...|.|..|.::|  .||                  ...|:.||
Zfish   536 HFTFVTQTFPRILSERKEGPVVNTKLGSLRG--SYM------------------MAKGKDSVISS 580

  Fly   178 FLGIPYALPPTFEGRFKPPRVHRGWQ-LLQAVDFGPACPQPVRYTGATKGIM------------- 228
            :..||:|..|....|..||:....|| :..|....|.|.||       |.:|
Zfish   581 YFAIPFAKSPVGPLRLTPPQPADAWQGVRDATKQPPMCLQP-------KEVMVDLLATMPLKTEF 638

  Fly   229 -DMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLG 292
             ::.|||||||:|:| :..|..:|.||||:||||....|::::|..|.||::.|:|||.:.||||
Zfish   639 PEVSEDCLYLNIYTP-SKPGDNKKLPVMVWIHGGGLAFGSASIFDAHALAAYQDIVVVMVQYRLG 702

  Fly   293 ALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRN 357
            .|||.|||||::|||||:|||..||:||.:||..|.||..|:|:||..|||.||.||:::|.:.|
Zfish   703 LLGFFSTGDEHAPGNYGLLDQVAALQWVQENIHSFGGDPGSVTVFGESAGGVSASLLVLSPLSAN 767

  Fly   358 IVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCL--RTGRSFYELGNAE 420
            :..|.||:||:|..:..:..|..   :|:|.||.:.||.|.|:.|:|:|:  .|.....::...:
Zfish   768 LFHRAIAESGTAAMNAIMSPDPL---STARSLGNVSGCDISSTKKIVDCVMQMTEEDILKIAREQ 829

  Fly   421 FSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEA 485
            .           :|....|:.|            :||.::.:.|:::.:|:: :..|||||..:.
Zfish   830 V-----------LLRFGVTVDG------------QFLPKSVDELLQSQEFSK-VPLMTGVTDDDG 870

  Fly   486 AFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQY 550
            .|.:.  |.::|....||...|| |...:..|||.|...|:.|.:  :..:.....:...|||.:
Zfish   871 GFTLP--EFIAPPGWRDGMTKDQ-IMPFLPTYNYDLQDPGLAEIV--LKEYLGATTDKIKIRDGF 930

  Fly   551 INMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLN--TTVEALNLPQWRKYPHDIERYFLTGAPF-- 611
            ..::.|.::..|..::.....:...|||||...  ..:.....|.:....|..|..|:.|..|
Zfish   931 REIVGDFFFNLPARKLANYHRDTGAPVYMYEFQHPAYIFQNKRPSFVGCDHGDELLFVFGYCFGN 995

  Fly   612 ----MDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRY 672
                ::.|...:::.|.:..            |..:.||||.|||...   |:.....|..|..|
Zfish   996 GHIKVEGELSKEEQELCKTT------------MAYWGNFARTGNPNGP---GLVEWPKYGAEAEY 1045

  Fly   673 LNINTTYNSSILLNYRQTECAFWTQYLPTVI-----GVLVPT----------------------- 709
            |.|.....||  .|::.....|..:.||.:|     |.:|.|
Zfish  1046 LGIGLEQKSS--KNFKGNHFHFMIEKLPQIIKEWKEGPVVETKLGSLRGAFLTVKGKDTIVNSYL 1108

  Fly   710 ---------------YPPTTEYWW-------EPKEPLQ--------IAFWSMSVA-------CFF 737
                           .|...|.|.       :|:..||        :.|.||.|.       |.:
Zfish  1109 GVPFAKPPVGPLRLARPQAAEKWQGVRDATKQPRMCLQERQMTVTELEFLSMDVEVPEVSEDCLY 1173

  Fly   738 LIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLE-------------PEQDT------------ 777
            |.:...:       ...|.|:.....|:|:|.||.             ..||.
Zfish  1174 LNIYTPV-------KPGQGDKKLPVMVWIHGGGLSLGSASMYDGSVLAAYQDVVVVLIQYRLGLL 1231

  Fly   778 --RGVDNAHMVTNHHALRS-------RDNIYEYRDSPSTKTLASKAH---TDTTSLRSP--SSLA 828
              ....:.|...|:..|..       ::||:.:...|.:.|:..::.   :.:|.:.||  |.|.
Zfish  1232 GFLSTGDEHAPGNYGFLDQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSTLILSPLASGLF 1296

  Fly   829 MTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQN---GSTAKV 873
            ....:.|..:...|:.:.:       ..:||.|...|.|   .|:||:
Zfish  1297 HRAIAESGTAFWDGLVMAD-------PFQRAQTAAKQCNCDSSSSAKI 1337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	175/585 (30%)
		PRK13335	818..>918	CDD:139494	15/61 (25%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:395084	16/67 (24%)
		COesterase	553..1065	CDD:395084	175/588 (30%)
		COesterase	1079..1592	CDD:395084	46/273 (17%)