Protein Alignment Gli and NLGN3

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 236/840 - (28%)
• Similarity: 341/840 - (40%)
• Gaps: 209/840 - (24%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|::|:::|.:|     |.|           ..::|....:||:|||.||..|.||.||.....
Human    44 VNTHFGKLRGARV-----PLP-----------SEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPS 92

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG-----ATKGIMDMDEDCLYLNVYSP------- 242
            |. :..|..|.|.|||           ||.:|.     ||. |.:.:|||||||||.|
Human    93 WSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATY-IQEPNEDCLYLNVYVPTEDVKRI 156

  Fly   243 --------------KTGAGVAQK--------------------YPVMVYIHGGEFIRGASNLFQG 273
                          |.|:|..::                    .|||||||||.::.|..|:..|
Human   157 SKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDG 221

  Fly   274 HILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFG 338
            .||||:.:|:|:|||||:|.||||||||:.:.||||:|||..|||||.:||.||.||...||:||
Human   222 SILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFG 286

  Fly   339 PGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKL 403
            .|.|.:...||.::..:..:.:|.|.||||||:.||:   .|:....:.:|...:||::..:..:
Human   287 SGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAV---NYQPVKYTSLLADKVGCNVLDTVDM 348

  Fly   404 VNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAG 468
            |:|||. :|..||...:..|......:|||:|.: .:|.|                 ||.|:..|
Human   349 VDCLRQ-KSAKELVEQDIQPARYHVAFGPVIDGD-VIPDD-----------------PEILMEQG 394

  Fly   469 KFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKY 532
            :| .|...|.||...|...||  ...:.|...:.|..||..:...|.. |.|....:.:.|.||:
Human   395 EF-LNYDIMLGVNQGEGLKFV--EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKF 456

  Fly   533 IYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKY 597
            :||.|.|.:|....|...:.:.:|..:..|......|......|.|.|......::|..|.|...
Human   457 MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDA 521

  Fly   598 PHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVL 658
            .|..|..::.|.|.: .|:.||..       ::.||..:|...|..:||||:.|:   |.||...
Human   522 AHGDEVPYVFGVPMVGPTDLFPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTK 579

  Fly   659 GMHFQRAYQGEIR----------YLNINTTYNSSILLNYRQTECAFWTQYLP-----------TV 702
            .:|.:.....|:.          ||:|.  ....:..:||.|:.|||...:|           |.
Human   580 FIHTKANRFEEVAWSKYNPRDQLYLHIG--LKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTS 642

  Fly   703 IGVLVPTYPPTTEY-----------WWEPKEP-LQIAF--------W------------------ 729
            ....||  ||.|.:           .|..|.| :..|:        |
Human   643 TTTKVP--PPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYS 705

  Fly   730 ---SMSVA----CFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGE----GLEPEQDTRGVDNA 783
               |:::|    ..||.|| ....:.:|..||:.:............    |..||::...:
Human   706 TELSVTIAVGASLLFLNVL-AFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEELAAL--- 766

  Fly   784 HMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTT----------SLRSPSSLAMTQKS 833
            .:...||         |....|...||...|..|.|          .|.:|:::.|...|
Human   767 QLGPTHH---------ECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNS 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	197/630 (31%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	197/630 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		10/50 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920