DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and CG10175

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	612	Identity:	179/612 - (29%)
Similarity:	275/612 - (44%)	Gaps:	103/612 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 SLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGR 192
            ||..||::..||:.|:|:| :...|.:.:...:|.               |.|:.|..|||...|
  Fly   147 SLRKEREIVATTSLGKVRG-RYQKYRSGERGGYYS---------------FKGMRYGAPPTGARR 195

  Fly   193 FKPPRVHRGWQ-LLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYS---PKTGAGVAQ-KY 252
            |:.....:.|. :..|...|.:||.........||    |||||::||::   ||......| |.
  Fly   196 FRAAEPEKPWSGIRDASREGQSCPHKNMILDTFKG----DEDCLFVNVFTTQMPKDDESAEQPKL 256

  Fly   253 PVMVYIHGGEFIRGASNLF---QGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQA 314
            ||||::|||.|..|:.|.|   ..:::|.  |:|:||||||||.||||:.|.: :|||.|:.||.
  Fly   257 PVMVWLHGGGFSFGSGNSFLYGPDYLVAE--DIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQV 318

  Fly   315 MALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWAL-IQD 378
            :||:||.|||..|.||.|.:|:||..||.:|..||:::.|.:.:..|.|:||||||..|:: ...
  Fly   319 LALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASS 383

  Fly   379 KYRAQNTSRVLGQLLGCSIES---------SWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVL 434
            ..||...:..||.:.....|.         :.|||....|..:..:..|     .:| .|:.||:
  Fly   384 SQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRN-----NIG-LPFVPVV 442

  Fly   435 DHNFTLPGDDWYEGWREKDW---RFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV---AQNE 493
            :       ..|.:..:|:.:   .||||.|..:..:..||.::.||||..|.||..|:   .:|.
  Fly   443 E-------GYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNP 500

  Fly   494 SLSPYYELD-GRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDL 557
            .|....|.| ||...|.:       |.|.:.:.|...|:..|.........::  |:.|.:|:||
  Fly   501 QLLSIIENDFGRLVPQDL-------NVTESHDRVTREIRSFYLGSKHVGIESV--DEMIALLTDL 556

  Fly   558 YYRAPVDQMVKLMLE-QKVPVYMY------VLNTTVEALNLPQWRKYP---HDIERYFLTGAPFM 612
            .:...:.:..:...: ...|||||      .|......|.:|:    |   |..|..:|....|.
  Fly   557 MFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPR----PGVCHGDELGYLFKFGFF 617

  Fly   613 DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQR-------AYQGEI 670
            :....||...:|          :.:..::.:||||:||:|||.....|...:       .....:
  Fly   618 NLSLDPKSMEVQ----------VKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSL 672

  Fly   671 RYLNINTTYNSSILLNYRQTECAFWTQ 697
            .|::|:.  |.::..|.......||.:
  Fly   673 NYMDISA--NLAMKTNPEPERQRFWDE 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	173/602 (29%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	173/598 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.810