Protein Alignment Gli and Ces1b

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001074841.1
• Gene: Ces1b / 382044
• MGIID: 3779470
• Length: 567
• Species: Mus musculus
• Alignment Length: 605
• Identity: 175/605 - (28%)
• Similarity: 273/605 - (45%)
• Gaps: 114/605 - (18%)

  Fly   161 YRPYHSTVDRVMGE--------------CSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQ-AVDF 210
            :.|....||...|:              .:||||:|:|.||....||.||.....|..:: |..:
Mouse    19 HSPSSPVVDTTQGKILGKYTSLEGFEHPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNATSY 83

  Fly   211 GPACPQPVRYTGATKGIMDM------------DEDCLYLNVYSPKTGAGVAQK--YPVMVYIHGG 261
            .|.|.|.   ..|.:.:.||            .|||||||:|||   |.:.:.  .||||:||||
Mouse    84 PPMCSQD---AVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSP---ADLTKSSLLPVMVWIHGG 142

  Fly   262 EFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEF 326
            ..:.|.::|:.|..|::..:|||||:.||||..|..|||||:|.||:..|||..|||||.|||..
Mouse   143 GLMTGGASLYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIAN 207

  Fly   327 FNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQ 391
            |.|:.:|:|:||..|||.|..:|:::|..:|:..|.|::|...|.:..:..|.. |.:.|:::..
Mouse   208 FGGNPDSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSVVLENIVITLDLV-ACDLSQMIAT 271

  Fly   392 LLGCSIESSWKLVNCLR--TGRSFYEL---------GNAEFSPQVGSFPWGPVLDHNFTLPGDDW 445
            :.||:..||..:|.|||  |.....|:         |.|. |.:..:.....|:| ...||
Mouse   272 VSGCNDTSSTAMVQCLRQKTENELLEITVKLEVTKVGGAA-SAKKDNTSMSTVID-GVVLP---- 330

  Fly   446 YEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQ--NESLSPYYELDGRFFDQ 508
                         :.||.::....|: .:.|:.|...||..:.:..  .:.||     :|:..::
Mouse   331 -------------KAPEEILAEKSFS-TVPYIVGFNKQEFGWIIPTMLGDLLS-----EGKMNEE 376

  Fly   509 KIREHVFRYNYTLNPNGVYEAI------KYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMV 567
            .....:.|::..||   :.|::      ||: ....||...   ||..::|.||:::..|...:.
Mouse   377 TASLLLRRFHSDLN---ISESLIPAVIEKYL-RGTDDPAKK---RDLLLDMFSDVFFGIPAVLLS 434

  Fly   568 KLMLEQKVPVYMYVLNTTVEALN--LPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTD 630
            :.:.:..|..|||........::  .||..:..|..|.:.:.|.|.:       ||..     ::
Mouse   435 RSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFSVFGIPLL-------KEGT-----SE 487

  Fly   631 NDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFW 695
            .:.|:|...|:.:.||||.|||..:   |:.....|..:..||.|..|...:..|  :..|.|||
Mouse   488 EETNLSKMVMKFWANFARNGNPNGE---GLPHWPEYDEKEGYLQIGATTQQAQRL--KAEEVAFW 547

  Fly   696 TQYLPTVIGVLVPTYPPTTE 715
            |:        |:...||.|:
Mouse   548 TE--------LLAKNPPETD 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	168/583 (29%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	168/583 (29%)
		Aes	<121..>239	CDD:223730	57/120 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740