Protein Alignment Gli and Glt

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Alignment Length: 996
• Identity: 199/996 - (19%)
• Similarity: 325/996 - (32%)
• Gaps: 352/996 - (35%)

  Fly    17 LLVLIGTCFIQTRGQTRDPRFYSRPGVDYHWPNPG-DPDYRTYTFNDRRYGHYQPNGYGANYPGR 80
            ||:::..|                 |...|..:.| .|||..|:..|.|
  Fly     4 LLLVLALC-----------------GAQVHAHSVGLRPDYNDYSDEDTR---------------- 35

  Fly    81 NPPGQYPQGMPNEDRFRFDPNDPNARTQFPGVLAGWREDLQGKQRRDSLTLERDVFVTTNYGQVQ 145
                  ...:|       :|..|          ..|:.:.:..|.::::....:|      ||:.
  Fly    36 ------RDWLP-------EPLKP----------VPWQSETRYAQPQEAVVQAPEV------GQIL 71

  Fly   146 GFKVYMYDNPDPKSFYRPYHSTV-DRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQAVD 209
            |..               .|.|: :|.:   :.||||.|.            .|..|....||.
  Fly    72 GIS---------------GHKTIANRPV---NAFLGIRYG------------TVGGGLARFQAA- 105

  Fly   210 FGPACPQPVRYTGATKGIM---------DMD------------EDCLYLNVYSPKTGAGVAQKYP 253
                  ||:.|.|.....:         ::|            :|||.|::|:|:.    |.:.|
  Fly   106 ------QPIGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPEG----ANQLP 160

  Fly   254 VMVYIHGGEFIRGASNLFQ-GHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMAL 317
            |:|::||.....|.|...| .::|..  ||::|::||||...||||...:..|||..:.|..:||
  Fly   161 VLVFVHGEMLFDGGSEEAQPDYVLEK--DVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLAL 223

  Fly   318 RWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRA 382
            .|:..|:..|.|:...:||.|...|...|..|.::.:..|:.:::|.|||:||..: ||.:  :.
  Fly   224 EWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPY-LIDN--QP 285

  Fly   383 QNTSRVLGQLLGC---SIESSWK----LVNCL------RTGRSFYE--LGNAEFS-PQVGSF--- 428
            .:|.....:|..|   ||..|.:    |.:||      :...:|.:  |.|.... .|:|.|
  Fly   286 LDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLV 350

  Fly   429 ---PWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVA 490
               |.|                        ||...|.:|  |...:..:..:.|.|...:||.|:
  Fly   351 VGDPLG------------------------FLPSHPASL--ATNSSLALPMIIGATKDASAFIVS 389

  Fly   491 QNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNN------------ 543
                         |.:||..|         |....|.:.|..:......|:.:
  Fly   390 -------------RIYDQLAR---------LQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIF 432

  Fly   544 TIIRDQYINM---------LSD-LYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYP 598
            |.|::|..::         ||: :.|||||...:. ...:.||.|:|..:             |.
  Fly   433 TPIQEQTASLQTVAPGLLELSNYILYRAPVINSIS-QSYRSVPAYLYTFD-------------YR 483

  Fly   599 HDIERY--------FLTGAPFMDTE--FFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPT 653
            .:..|:        |...|...|..  .||......|  ....||::|...:..:.|||..|.|.
  Fly   484 GEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASR--LNPLDRSLSRALVTMWVNFATTGVPN 546

  Fly   654 PQQVLGMHFQRAYQGEIRYLN-------INTTYNSSILL-NYR----QTECAFWTQYLPTVIGVL 706
            |...:.......|...:|:.|       ::..:...|.| |||    .|     |.:.|.:....
  Fly   547 PSSGVWPQATSEYGPFLRFTNNQQSPLELDPHFGEGIYLPNYRVIYKPT-----TNFSPPITTTT 606

  Fly   707 VPTYPPTT----------EYW----------WEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRN 751
            ..|...||          ..|          |.|.:|..:.........|          |..|.
  Fly   607 TTTTTTTTTSRPYAYNPYANWQNRPSQQHPNWHPADPEYVRAQEARQQEF----------IRERE 661

  Fly   752 AKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHT 816
            .:|:..:..|:..:       |:|:.|.             :..:.|.:.|:...
  Fly   662 QRRREQQLRDQQRY-------PQQEPRE-------------QQDERIRQQREQEE---------- 696

  Fly   817 DTTSLRSPSSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASPPVEEK 881
                       .:.|:...:..|:....|:|   .:.:|.||....|.||.           .|:
  Fly   697 -----------RLRQQREQEERLRQQRELEE---RIRQQQEREQYEREQQE-----------REQ 736

  Fly   882 RLLQPLSSTPVTQLQAEPAKR 902
            |..:.|......:.|.:|.::
  Fly   737 REREELERQQREREQQQPEQQ 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	147/646 (23%)
		PRK13335	818..>918	CDD:139494	15/85 (18%)
Glt	NP_477504.1	COesterase	58..579	CDD:395084	142/636 (22%)
		Casc1_N	681..>717	CDD:464947	7/72 (10%)