DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and CG5397

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	143/573 - (24%)
Similarity:	218/573 - (38%)	Gaps:	161/573 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 QVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQA 207
            :|:||:     ||....:                .|||:.||.||....|:..|...|......|
  Fly    62 RVEGFR-----NPSTGIY----------------SFLGMHYAEPPVGPLRYSRPVYKRLAGDFNA 105

  Fly   208 VDFGPAC----PQ-PVRYTGATKGIMDMDEDCLYLNVYSPK-----TGAGVAQKYPVMVYIHGGE 262
            ...||.|    || |.|..|        |||||.||||:|:     ||      .||.|:||.|.
  Fly   106 TKHGPPCIQPHPQFPQRIIG--------DEDCLLLNVYTPQMPDETTG------LPVFVWIHPGG 156

  Fly   263 FIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFF 327
            :..|::..:....:|. ...:||...||||:||.:..|.:...||..:.|.|.|||||.|.|.:|
  Fly   157 YRYGSAAQYDATPMAQ-RGAIVVAPQYRLGSLGIMGDGTKQFDGNLAMFDLAAALRWVTDYISYF 220

  Fly   328 NGDRNSITLFGPGAGGASAGLLMVAPQTRNI--VRRVIAQSGSALADWALIQDKYRAQNTSRVLG 390
            .|:...:...|.|:|.|||..|.::|.:|:.  |..|:|.||:||:.:|:  ||...|:...| .
  Fly   221 GGNPKQVQAIGHGSGAASAMYLSMSPTSRSAGDVHGVVAMSGTALSQYAM--DKEPVQSVQEV-A 282

  Fly   391 QLLGCSIESSWKLVNCLRT-------------------GRSFYE--LGNAEFSPQVGSFPWGPVL 434
            ::.||...:..::|||||:                   ||:..:  .||..|.|.:.|      .
  Fly   283 KINGCPTGNELEIVNCLRSKSAEDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIES------E 341

  Fly   435 DHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAA------------- 486
            |....||.             .:...||..:::..|: .|..:||||..|.|
  Fly   342 DDGRALPS-------------LIVGEPEQQLKSSNFS-GIPLLTGVTKHETANSVTVETIEKVFG 392

  Fly   487 ----FFVAQNES---LSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFW--PDPNN 542
                |..:.::|   |:.:.::| :...|..:..:......|.|.        :...|  |...|
  Fly   393 SAEQFLGSLSDSLNKLTSFLKID-KLTGQIAKPELPGLTSVLTPT--------LQDVWKVPQALN 448

  Fly   543 NTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVL---NTTVEALNLPQWRKYPHDIERY 604
            ...:..:.:...:|:.:..|. .:...:..:..|.:||..   .|..:.:|
  Fly   449 VDQVLSKVVESTTDVLFNLPA-VLTTQVWSRLAPAFMYSFEYNGTKSKGIN-------------- 498

  Fly   605 FLTGAPFMDTEFFPKKEHLQRN-----MWTDNDRNMSHFFMQTYTNFARYGNP 652
            ||.|.|.:......|.|.:...     |:..||               .:|||
  Fly   499 FLKGLPIVSETAHDKPETVGHGDEIGYMFDAND---------------IFGNP 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	143/573 (25%)
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	143/573 (25%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	69/193 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.900