DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and Nlgn3

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	820	Identity:	236/820 - (28%)
Similarity:	338/820 - (41%)	Gaps:	189/820 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|::|:::|.:|     |.|           ..::|....:||:|||.||..|.||.||.....
Mouse    41 VNTHFGKLRGARV-----PLP-----------SEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPS 89

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG-----ATKGIMDMDEDCLYLNVYSPKTGAGVA 249
            |. :..|..|.|.|||           ||.:|.     ||. |.:.:|||||||||.|......|
Mouse    90 WSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATY-IQEPNEDCLYLNVYVPTEDGSGA 153

  Fly   250 QKY---------------------PVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGA 293
            :|.                     |||||||||.::.|..|:..|.:|||:.:|:|:|||||:|.
Mouse   154 KKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGV 218

  Fly   294 LGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNI 358
            ||||||||:.:.||||:|||..|||||.:||.||.||...||:||.|.|.:...||.::..:..:
Mouse   219 LGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGL 283

  Fly   359 VRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSP 423
            .:|.|.||||||:.||:   .|:....:.:|...:||::..:..:|:|||. :|..||...:..|
Mouse   284 FQRAIIQSGSALSSWAV---NYQPVKYTSLLADKVGCNVLDTVDMVDCLRQ-KSAKELVEQDIQP 344

  Fly   424 QVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFF 488
            ......:|||:|.: .:|.|                 ||.|:..|:| .|...|.||...|...|
Mouse   345 ARYHVAFGPVIDGD-VIPDD-----------------PEILMEQGEF-LNYDIMLGVNQGEGLKF 390

  Fly   489 VAQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYIN 552
            |  ...:.|...:.|..||..:...|.. |.|....:.:.|.||::||.|.|.:|....|...:.
Mouse   391 V--EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVA 453

  Fly   553 MLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFM-DTEF 616
            :.:|..:..|......|......|.|.|......::|..|.|....|..|..::.|.|.: .|:.
Mouse   454 LFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDL 518

  Fly   617 FPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIR------- 671
            ||..       ::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.
Mouse   519 FPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPR 576

  Fly   672 ---YLNINTTYNSSILLNYRQTECAFWTQYLP-----------TVIGVLVPTYPPTTEY------ 716
               ||:|.  ....:..:||.|:.|||...:|           |.....||  ||.|.:
Mouse   577 DQLYLHIG--LKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVP--PPDTTHSSHITR 637

  Fly   717 -----WWEPKEP-LQIAF--------W---------------------SMSVA----CFFLIVLV 742
                 .|..|.| :..|:        |                     |:::|    ..||.||
Mouse   638 RPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVL- 701

  Fly   743 VICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHH----ALRSRDNIYEYRD 803
            ....:.:|..||:.            |.|......||.....:.|...    ||:.....:|...
Mouse   702 AFAALYYRKDKRRQ------------EPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEA 754

  Fly   804 SPSTKTLASKAHTDTT----------SLRSPSSLAMTQKS 833
            .|...||...|..|.|          .|.:|:::.|...|
Mouse   755 GPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNS 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	195/610 (32%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	195/610 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668		10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920