Protein Alignment Gli and Ces1a

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001013786.2
• Gene: Ces1a / 244595
• MGIID: 3648919
• Length: 563
• Species: Mus musculus
• Alignment Length: 611
• Identity: 176/611 - (28%)
• Similarity: 272/611 - (44%)
• Gaps: 125/611 - (20%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|..|:|.|..:.:..:..|                 .:||||:|:|.||....||.||:....
Mouse    26 VDTLQGKVMGKYISLEGSAQP-----------------VAVFLGVPFAKPPLGPLRFAPPQPAET 73

  Fly   202 WQLLQ-AVDFGPACPQ-----PVR---YTGATKGI-MDMDEDCLYLNVYSPKTGAGVAQKYPVMV 256
            |..:: ...:.|.|.|     ||.   :|...:.: ::..|||||||:||| |......:.||||
Mouse    74 WSSVKNTTSYPPMCSQITGVGPVLSDVFTNQLENVPLEYSEDCLYLNIYSP-TDLTSKDRLPVMV 137

  Fly   257 YIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVY 321
            ::|||..:.|.::.|.|..|::..:||:|.:.||||..||||||||:|.||:|.|||..||:||.
Mouse   138 WVHGGGLLSGGASTFDGLALSTHENVVIVVIQYRLGIWGFLSTGDEHSRGNWGHLDQVAALQWVQ 202

  Fly   322 DNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTS 386
            :||..|.||.:|:||||..|||.|..:|:::|.|:|:.:|.|::||.||......:...||....
Mouse   203 NNIANFGGDPSSVTLFGESAGGESVSVLVLSPLTKNLFQRAISESGVALTPCLFRETTRRAAEQV 267

  Fly   387 RVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNF---TLPGDDWYEG 448
            .:   ..||...:|..:|:|||. ::..||             ....|...|   .|.||.
Mouse   268 AI---ATGCVATTSADIVHCLRE-KTEEEL-------------LATTLKMKFFALDLLGDP---- 311

  Fly   449 WREKDWRFLT---------QTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGR 504
              .:.:.|||         :.||.::....|| .:.|:.|:..||..:|:    .:...|.|...
Mouse   312 --RESYPFLTTVIDGVVLPKAPEEILAEKSFN-TVPYIVGINKQEFGWFI----PMMMGYPLSEG 369

  Fly   505 FFDQKIREHVFRYNYTLNPNGVYEAI------KYI-YTFWPDPNNNTIIRDQYINMLSDLYYRAP 562
            ..|||....:...:|.|  ..:.:.:      ||: .:..||..     :|.:::|:.|:.:..|
Mouse   370 KLDQKSATSLLWKSYPL--TNISKELTPVATEKYLGGSDCPDKK-----KDLFLDMMGDVLFAVP 427

  Fly   563 VDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYP--------------HDIERYFLTGAPFMD 613
            ...:.:...:...|.|||            :::.:|              |..|.|.:.|.||:
Mouse   428 SVIVARYHRDAGAPTYMY------------EFKYHPSFVSDMRPKTVIADHGDEVYSVWGTPFL- 479

  Fly   614 TEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTT 678
                  ||..     ::.:.|:|...|:.:.||||.|||..:   |:.....|..:..||.|..|
Mouse   480 ------KEGA-----SEEEINLSTMMMKFWGNFARNGNPNGE---GLPHWPEYGEKESYLQIGAT 530

  Fly   679 YNSSILLNYRQTECAFWTQYLPTVIG 704
            ...:..|  :..|.||||......:|
Mouse   531 TQQAQRL--KDKEVAFWTSLRAMEVG 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	172/600 (29%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	169/589 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740