DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and Ces2b

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	605	Identity:	171/605 - (28%)
Similarity:	255/605 - (42%)	Gaps:	115/605 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 TNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQ 203
            |:.|||:|..|::.|                 .......|||||:|.||....||.||.....|.
Mouse    38 THTGQVRGSLVHVKD-----------------TKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWS 85

  Fly   204 LLQAVDFGPA-CPQPVRYTGATKGI------MDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGG 261
            .::.....|| |.|.:   |..|.|      :...|||||||:|:| ..|......||||:||||
Mouse    86 GVRDGTAHPAMCLQNL---GVMKEIKLKLPPVSTSEDCLYLNIYTP-AHAHEGSNLPVMVWIHGG 146

  Fly   262 EFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEF 326
            ..:.|.::::.|.:||:..|:||||:.||||.|||.||||:::.||:|.|||..||||:..||..
Mouse   147 GLVAGMASMYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARGNWGFLDQVAALRWIQQNIAH 211

  Fly   327 FNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQ 391
            |.|..:.:|:||..|||.|....:|:|.::.:....|.:||.||..: ||.|  .::..|..:.:
Mouse   212 FGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPY-LITD--TSEMVSTTVAK 273

  Fly   392 LLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNF-------TLPGDDWYE-- 447
            |.||....|..||.||| |:|..|:  ...:..|...|  .|:|..|       .|..:|::.
Mouse   274 LSGCEAMDSEALVRCLR-GKSEAEI--LAINKLVQMIP--AVVDGEFFPRHPKELLASEDFHPVP 333

  Fly   448 ----------GWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELD 502
                      ||.........||.:.:.|     .|:|.:...||.:..              |.
Mouse   334 SIIGVNNDEFGWTIPVVMGSAQTIKEITR-----ENLQAVLKNTTAQLM--------------LP 379

  Fly   503 GRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMV 567
            ....|..:.|::                       .|..:...::.|:..|:.|..:..|..| |
Mouse   380 PECSDLLMEEYM-----------------------GDTEDAQTLQIQFTEMMEDFMFVIPALQ-V 420

  Fly   568 KLMLEQKVPVYMYVLNTTVEALN--LPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTD 630
            .........||.|.....:.:|.  .|...|..|..|..|:.|..|.|.:.          .:|:
Mouse   421 AYFQRSHASVYFYEFQHQIASLKDVRPTHVKADHADEIPFVFGYFFWDMKL----------DFTE 475

  Fly   631 NDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFW 695
            .::.:|...|:.:.||||:|||..:   |:.:......:.:||.::|.......|..|:.:  ||
Mouse   476 GEKLLSRRMMKYWANFARHGNPNSE---GLPYWPVMDHDEQYLQLDTQPAVGRALKSRRLQ--FW 535

  Fly   696 TQYLPTVIGVLVPTYPPTTE 715
            |:.|...|..|..:....||
Mouse   536 TKTLSQKIQELRASQDKHTE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	163/583 (28%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	163/583 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740