DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and NLGN1

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	821	Identity:	225/821 - (27%)
Similarity:	349/821 - (42%)	Gaps:	178/821 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPT 188
            |:.|.:    |..|.||:|:::|.|..:.                :.::|....|||:|||.|||
Human    46 QKLDDV----DPLVATNFGKIRGIKKELN----------------NEILGPVIQFLGVPYAAPPT 90

  Fly   189 FEGRFKPPRVHRGW-QLLQAVDFGPACPQ------------PVRYTG----ATKGIMDMDEDCLY 236
            .|.||:||.....| .:..|..|.|.|||            ||.:|.    .:..:.|..|||||
Human    91 GERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLY 155

  Fly   237 LNVYSPKTGAGVAQKY----------------------PVMVYIHGGEFIRGASNLFQGHILASF 279
            ||:|.|.....:.:|.                      |||||||||.::.|..||:.|.:|||:
Human   156 LNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASY 220

  Fly   280 YDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGA 344
            .:|:|:|:|||||.||||||||:.:.||||:||...||||..:||.||.||...||:||.||||:
Human   221 GNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGS 285

  Fly   345 SAGLLMV---------APQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESS 400
            ...||.:         :..|:.:.:|.|||||:||:.||:   .::....:|:|...:||::..:
Human   286 CVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAV---SFQPAKYARMLATKVGCNVSDT 347

  Fly   401 WKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLI 465
            .:||.||:. :.:.||.:.:..|......:|||:|.: .:|.|                 |:.|:
Human   348 VELVECLQK-KPYKELVDQDIQPARYHIAFGPVIDGD-VIPDD-----------------PQILM 393

  Fly   466 RAGKFNRNIQYMTGVTTQEAAFFVA----QNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNG 525
            ..|:| .|...|.||...|...||.    .::.:|      ...||..:...|.. |.|....:.
Human   394 EQGEF-LNYDIMLGVNQGEGLKFVENIVDSDDGIS------ASDFDFAVSNFVDNLYGYPEGKDV 451

  Fly   526 VYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALN 590
            :.|.||::||.|.|.:|....|...:.:.:|..:.||......|......|.|.|......:...
Human   452 LRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQ 516

  Fly   591 LPQWRKYPHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN--- 651
            :|.|....|..|..::.|.|.: .||.||..       ::.||..:|...|..:||||:.|:
Human   517 VPAWADAAHGDEVPYVLGIPMIGPTELFPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQ 574

  Fly   652 PTPQQVLGMH----------FQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGV- 705
            |.||....:|          :.|..|.:..||:|.  ....:..:||..:...|.:.:|.:..:
Human   575 PVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIG--LKPRVKEHYRANKVNLWLELVPHLHNLN 637

  Fly   706 ------LVPTYPPTTEYWWEPKE----PLQIAF-------------------------WSMSVA- 734
                  ...|..|:|:..:.|..    |:..||                         .|:::|
Human   638 DISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAV 702

  Fly   735 ---CFFLIVLVVICCIMWRNAKRQSD---RFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHHALR 793
               ..||.:| ....:.::..||:.|   |...:....|......|::...:...|...:|..
Human   703 GASLLFLNIL-AFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHEC-- 764

  Fly   794 SRDNIYEYR-----DSPSTKTLASKAHTDTTSLRSPSSLAM 829
              ::|:.:.     ..|...|||.:...|...|.:|:::.|
Human   765 --ESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITM 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	192/627 (31%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	191/626 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920