Protein Alignment Gli and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 893
• Identity: 245/893 - (27%)
• Similarity: 372/893 - (41%)
• Gaps: 209/893 - (23%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.||||::||.:     .|.|           ..::|....:||:|||.|||.|.||:||.....
Human    48 VNTNYGKIQGLR-----TPLP-----------SEILGPVEQYLGVPYASPPTGERRFQPPESPSS 96

  Fly   202 WQ-LLQAVDFGPACPQ------------PVRYTGATKGIM----DMDEDCLYLNVYSP-KTGAGV 248
            |. :..|..|...|||            |:.:|.:...:|    |.:|||||||:|.| :.|..:
Human    97 WTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNI 161

  Fly   249 AQ---------------------KYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLG 292
            .:                     |.|||||||||.::.|..|:..|.||||:.:|:|:|:|||||
Human   162 KRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLG 226

  Fly   293 ALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRN 357
            .||||||||:.:.||||:|||..||||:.:|:..|.||...:|:||.|||.:...||.::..:..
Human   227 ILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEG 291

  Fly   358 IVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFS 422
            :.::.|.|||:||:.||:   .|:....:|:|...:||::..:..:|.||: .:::.||.....:
Human   292 LFQKAIIQSGTALSSWAV---NYQPAKYTRILADKVGCNMLDTTDMVECLK-NKNYKELIQQTIT 352

  Fly   423 PQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAF 487
            |......:|||:|.: .:|.|                 |:.|:..|:| .|...|.||...|...
Human   353 PATYHIAFGPVIDGD-VIPDD-----------------PQILMEQGEF-LNYDIMLGVNQGEGLK 398

  Fly   488 FV---AQNESLSPYYELDG---RFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTI 545
            ||   ..||        ||   ..||..:...|.. |.|....:.:.|.||::||.|.|..|...
Human   399 FVDGIVDNE--------DGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPET 455

  Fly   546 IRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAP 610
            .|...:.:.:|..:.||......|..:...|.|.|......::...|.|....|..|..::.|.|
Human   456 RRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIP 520

  Fly   611 FM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIR 671
            .: .||.|...       ::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.
Human   521 MIGPTELFSCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVA 578

  Fly   672 YLNINTTYNSSILL------------NYRQTECAFWT-------------QYLPTVIGVLVP--- 708
            :    :.||....|            :||.|:.|||.             ||:.|...|..|
Human   579 W----SKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMT 639

  Fly   709 TYPPTT-----EYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSD--RFYDEDVFI 766
            ::|..|     :.|...|.|      :::.|               .|.|...|  :...||..:
Human   640 SFPYGTRRSPAKIWPTTKRP------AITPA---------------NNPKHSKDPHKTGPEDTTV 683

  Fly   767 NGEGLEPEQD-------TRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSP 824
            .   :|.::|       |..|..:.:..|..|..:   :|..:|....:|     |      |.|
Human   684 L---IETKRDYSTELSVTIAVGASLLFLNILAFAA---LYYKKDKRRHET-----H------RHP 731

  Fly   825 SSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASPP---------VEE 880
            |....|....:....:..:||:      :||.|......|.|...|.::..||         .::
Human   732 SPQRNTTNDITHIQNEEIMSLQ------MKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDD 790

  Fly   881 KRLLQP--LSSTPVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTT 926
            ...:.|  ::..|.|.:..:|   :.|..:.||...||. :|...|||
Human   791 IPFMTPNTITMIPNTLMGMQP---LHTFKTFSGGQNSTN-LPHGHSTT 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	190/619 (31%)
		PRK13335	818..>918	CDD:139494	23/110 (21%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	190/619 (31%)