DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Nlgn2

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	710	Identity:	215/710 - (30%)
Similarity:	316/710 - (44%)	Gaps:	148/710 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 GANYPGRNPPGQYPQGMPNEDRFRFDPNDPNARTQFPGVLAGWREDLQGKQRRDSLTLERDVFVT 138
            ||...|..|.|..|.|                    ||:..|            ||..||...|.
Mouse    13 GAQRGGGGPGGGAPGG--------------------PGLGLG------------SLGEERFPVVN 45

  Fly   139 TNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQ 203
            |.||:|:|.:                ....:.::|....|||:|||.||....||:||.....|.
Mouse    46 TAYGRVRGVR----------------RELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWP 94

  Fly   204 -LLQAVDFGPACPQ-----------PVRYT----GATKGIMDMDEDCLYLNVY------------ 240
             :..|....|||||           ||.:|    .|...:.:..|||||||:|
Mouse    95 GVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKR 159

  Fly   241 ------SPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLST 299
                  .|.|....:.|.|||:::|||.::.|..|:|.|.:||::.:|:|||||||||.||||||
Mouse   160 DEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLST 224

  Fly   300 GDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIA 364
            ||:.:.||||:|||..||||:.:||..|.||...||:||.|||.:...||:::..:..:.::.||
Mouse   225 GDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIA 289

  Fly   365 QSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFP 429
            |||:|::.|::   .|:....:|:|...:||..|.|.:.|.|||. :|..||.:.:..|......
Mouse   290 QSGTAISSWSV---NYQPLKYTRLLAAKVGCDREDSTEAVECLRR-KSSRELVDQDVQPARYHIA 350

  Fly   430 WGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV---AQ 491
            :|||:|.: .:|.|                 ||.|::.|:| .|...:.||...|...||   |:
Mouse   351 FGPVVDGD-VVPDD-----------------PEILMQQGEF-LNYDMLIGVNQGEGLKFVEDSAE 396

  Fly   492 NESLSPYYELDG---RFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYIN 552
            :|        ||   ..||..:...|.. |.|....:.:.|.||::||.|.|.:|..:.|...:.
Mouse   397 SE--------DGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLA 453

  Fly   553 MLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMD-TEF 616
            :.:|..:.||.....||..:.:.|||.|......:|...|:|....|..|..::.|.|.:. |:.
Mouse   454 LFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDL 518

  Fly   617 FPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMH----------FQRAYQG 668
            ||..       ::.||..:|...|..:||||:.|:   |.||....:|          :.:....
Mouse   519 FPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSK 576

  Fly   669 EIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYPPTTEY-----WWEPKEP 723
            |.:||:|.  ....:..|||..:.|||.:.:|.:..:....:..||..     .|.|:.|
Mouse   577 EKQYLHIG--LKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTP 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	193/615 (31%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	193/614 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661		3/12 (25%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920